A Reduction of Calcineurin Inhibitors May Improve Survival in Patients with De Novo Colorectal Cancer after Liver Transplantation

Ramin Raul Ossami Saidy, Elisa Wegener, Deniz Uluk, Luca Dittrich, Wenzel Schöning, Georg Lurje, Robert Öllinger, Dominik Paul Modest, Frank Tacke, Oliver Haase, Johann Pratschke, Dennis Eurich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background and Objectives: After liver transplantation (LT), long-term immunosuppression (IS) is essential. IS is associated with de novo malignancies, and the incidence of colorectal cancer (CRC) is increased in LT patients. We assessed course of disease in patients with de novo CRC after LT with focus of IS and impact on survival in a retrospective, single-center study. Materials and Methods: All patients diagnosed with CRC after LT between 1988 and 2019 were included. The management of IS regimen following diagnosis and the oncological treatment approach were analyzed: Kaplan–Meier analysis as well as univariate and multivariate analysis were performed. Results: A total of 33 out of 2744 patients were diagnosed with CRC after LT. Two groups were identified: patients with restrictive IS management undergoing dose reduction (RIM group, n = 20) and those with unaltered regimen (maintenance group, n = 13). The groups did not differ in clinical and oncological characteristics. Statistically significant improved survival was found in Kaplan–Meier analysis for patients in the RIM group with 83.46 (8.4–193.1) months in RIM and 24.8 (0.5–298.9) months in the maintenance group (log rank = 0.02) and showed a trend in multivariate cox regression (p = 0.054, HR = 14.3, CI = 0.96–213.67). Conclusions: Immunosuppressive therapy should be reduced further in patients suffering from CRC after LT in an individualized manner to enable optimal oncological therapy and enable improved survival.

Original languageEnglish
Article number1755
JournalMedicina (Lithuania)
Issue number12
StatePublished - Dec 2022
Externally publishedYes


  • colorectal carcinoma
  • de novo malignancy
  • immunosuppression
  • liver transplantation


Dive into the research topics of 'A Reduction of Calcineurin Inhibitors May Improve Survival in Patients with De Novo Colorectal Cancer after Liver Transplantation'. Together they form a unique fingerprint.

Cite this