A reduction in the accumulation of H3-norepinephrine in experimental hypertension

Jacques de Champlain; Lawrence R. Krakoff; Julius Axelrod

doi:10.1016/0024-3205(66)90064-6

A reduction in the accumulation of H³-norepinephrine in experimental hypertension

Jacques de Champlain
, Lawrence R. Krakoff
, Julius Axelrod

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Uninephrectomized rats made hypertensive by the combined administration of desoxycorticosterone and high sodium diet showed a decreased ability to accumulate tritiated norepinephrine in the heart. The level of endogenous cardiac norepinephrine was also reduced. A highly significant inverse relationship was observed between the blood pressure and the accumulation of tritiated norepinephrine in the heart.

Original language	English
Pages (from-to)	2283-2291
Number of pages	9
Journal	Life Sciences
Volume	5
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(66)90064-6
State	Published - Dec 1966
Externally published	Yes

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10.1016/0024-3205(66)90064-6

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@article{2872897598364781a9d2b5f82ed68109,

title = "A reduction in the accumulation of H3-norepinephrine in experimental hypertension",

abstract = "Uninephrectomized rats made hypertensive by the combined administration of desoxycorticosterone and high sodium diet showed a decreased ability to accumulate tritiated norepinephrine in the heart. The level of endogenous cardiac norepinephrine was also reduced. A highly significant inverse relationship was observed between the blood pressure and the accumulation of tritiated norepinephrine in the heart.",

author = "\{de Champlain\}, Jacques and Krakoff, \{Lawrence R.\} and Julius Axelrod",

year = "1966",

month = dec,

doi = "10.1016/0024-3205(66)90064-6",

language = "English",

volume = "5",

pages = "2283--2291",

journal = "Life Sciences",

issn = "0024-3205",

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T1 - A reduction in the accumulation of H3-norepinephrine in experimental hypertension

AU - de Champlain, Jacques

AU - Krakoff, Lawrence R.

AU - Axelrod, Julius

PY - 1966/12

Y1 - 1966/12

N2 - Uninephrectomized rats made hypertensive by the combined administration of desoxycorticosterone and high sodium diet showed a decreased ability to accumulate tritiated norepinephrine in the heart. The level of endogenous cardiac norepinephrine was also reduced. A highly significant inverse relationship was observed between the blood pressure and the accumulation of tritiated norepinephrine in the heart.

AB - Uninephrectomized rats made hypertensive by the combined administration of desoxycorticosterone and high sodium diet showed a decreased ability to accumulate tritiated norepinephrine in the heart. The level of endogenous cardiac norepinephrine was also reduced. A highly significant inverse relationship was observed between the blood pressure and the accumulation of tritiated norepinephrine in the heart.

UR - https://www.scopus.com/pages/publications/0013993068

U2 - 10.1016/0024-3205(66)90064-6

DO - 10.1016/0024-3205(66)90064-6

M3 - Article

C2 - 5972783

AN - SCOPUS:0013993068

SN - 0024-3205

VL - 5

SP - 2283

EP - 2291

JO - Life Sciences

JF - Life Sciences

IS - 24

ER -

A reduction in the accumulation of H3-norepinephrine in experimental hypertension

Abstract

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A reduction in the accumulation of H³-norepinephrine in experimental hypertension