A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

William Matthews, Craig T. Jordan, Gordon W. Wiegand, Drew Pardoll, Ihor R. Lemischka

Research output: Contribution to journalArticlepeer-review

514 Scopus citations

Abstract

To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.

Original languageEnglish
Pages (from-to)1143-1152
Number of pages10
JournalCell
Volume65
Issue number7
DOIs
StatePublished - 28 Jun 1991
Externally publishedYes

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