@article{b407c76af84e4b2da4b4623ee7516c84,
title = "A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations",
abstract = "To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.",
author = "William Matthews and Jordan, {Craig T.} and Wiegand, {Gordon W.} and Drew Pardoll and Lemischka, {Ihor R.}",
note = "Funding Information: We wish to thank Drs. Jean Schwarzbauer. Thomas Shenk, and Philip Sharp for critical comments on the manuscript. We also gratefully acknowledge Jerome Zawadzki for expert flow cytometry and Mark Flocco for excellent oligonucleotide production. The patient and expert assistance of Bernice Sikorski and Diane Vail in preparing the manuscript is greatly appreciated. We also gratefully acknowledge the help of Andrea Sirak and Marc Gavin in the initial stages of this work. The work was supported by National Institutes of Health grants CA45339 and DK42Q89. William Matthews is the recipient of a postdoctoral fellowship from NIH.",
year = "1991",
month = jun,
day = "28",
doi = "10.1016/0092-8674(91)90010-V",
language = "English",
volume = "65",
pages = "1143--1152",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "7",
}