A Rare Presentation of Sarcomatoid Carcinoma of Duodenum: A Case Report

Jonathan Vincent Reyes, Tasur Seen, Bhanu Singh, Aaron Walfish

Research output: Contribution to journalArticlepeer-review


Sarcomatoid tumors are very rare biphasic tumors characterized by a mixture of malignant epithelial and mesenchymal cells that have been usually identified in the lungs with other documented cases in skin, bone, thyroid gland, salivary glands, breast, and genitourinary and gastrointestinal systems. They have an incidence estimated to be 0.5 to 0.8 per 100 000 per year. Three classic features include the presence of a genuine sarcomatous component, no transitional zone between carcinomatous and sarcomatous components, and immunohistochemistry of the sarcomatous component that is positive for mesenchymal markers and negative for epithelial markers. Sarcomatoid carcinoma of the gastrointestinal tract is rare but more commonly found within the stomach, gallbladder, and esophagus. Small bowel involvement is very rare.

Original languageEnglish
JournalJournal of Investigative Medicine High Impact Case Reports
StatePublished - 2022
Externally publishedYes


  • gastroenterology
  • hematology oncology


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