Abstract
A rapid and precise method for evaluating the miotic acitivity of chlinergic drugs was developed based on Long's method for measuring the rate of mydriasis. The rate of reversal of mydriasis developed previously in the intact mouse eye by a mild mydriatic (phencyclidine) is used to evaluate the miotic activity. The method provides a useful tool for measuring and comparing the miotic activity of acetylcholine agonists and cholinesterase inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 159-163 |
| Number of pages | 5 |
| Journal | Investigative Ophthalmology |
| Volume | 14 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |
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