A randomized, blinded clinical evaluation of a novel microwave device for treating axillary hyperhidrosis: The dermatologic reduction in underarm perspiration study

Dee Anna Glaser, William P. Coleman, Larry K. Fan, Michael S. Kaminer, Suzanne L. Kilmer, Robert Nossa, Stacy R. Smith, Kathryn F. O'Shaughnessy

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Background Duration of effect and effectiveness limit current options for treating axillary hyperhidrosis. A new microwave procedure for treatment of axillary hyperhidrosis has been tested. Study Design/Materials and Methods Adults with primary axillary hyperhidrosis were enrolled in a randomized, sham-controlled, blinded study. Subjects were required to have a Hyperhidrosis Disease Severity Scale (HDSS) score of 3 or 4 and baseline sweat production greater than 50 mg/5 min. Procedures were administered using a proprietary microwave energy device that isolates and heats target tissue. Responders were defined as subjects reporting a HDSS score of 1 or 2. Subjects were followed for 6 months (sham group) or 12 months (active group). Results Thirty days after treatment, the active group had a responder rate of 89% (72/81), and the sham group had a responder rate of 54% (21/39) (P <.001). Treatment efficacy was stable from 3 months (74%) to 12 months (69%), when follow-up ended. Adverse events were generally mild, and all but one resolved over time. Conclusions The procedure demonstrated statistically significant, long-term efficacy in sweat reduction. As with any new procedure, findings from this first investigational device study identified optimization strategies for the future.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalDermatologic Surgery
Volume38
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

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