A randomised trial of tamoxifen versus tamoxifen with aminoglutethimide in post-menopausal women with advanced breast cancer

R. Milsted, T. Habeshaw, S. Kaye, G. Sangster, F. Macbeth, J. Campbell-Ferguson, D. Smith, K. Calman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Sixty-six post-menopausal women with metastatic breast cancer were randomised to receive tamoxifen or tamoxifen with aminoglutethimide. The women in the tamoxifen group were virtually free of toxicity, whilst 45% of patients in the aminoglutethimide group had toxicity and 13% discontinued the drug because of this. Responses were seen in 19% of patients receiving tamoxifen alone and 23% of those receiving both drugs. There is no indication that the increased toxicity seen with the addition of aminoglutethimide to tamoxifen in this situation is justified by an increased response rate.

Original languageEnglish
Pages (from-to)272-273
Number of pages2
JournalCancer Chemotherapy and Pharmacology
Volume14
Issue number3
DOIs
StatePublished - Apr 1985
Externally publishedYes

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