A radiation hybrid map of mouse genes

Thomas J. Hudson, Deanna M. Church, Simon Greenaway, Huy Nguyen, April Cook, Robert G. Steen, William J. Van Etten, Andrew B. Castle, Mark A. Strivens, Pamela Trickett, Christine Heuston, Claire Davison, Anne Southwell, Rachel Hardisty, Anabel Varela-Carver, Andrew R. Haynes, Patricia Rodriguez-Tome, Hirofumi Doi, Minoru S.H. Ko, Joan PontiusLynn Schriml, Lukas Wagner, Donna Maglott, Steve D.M. Brown, Eric S. Lander, Greg Schuler, Paul Denny

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


A comprehensive gene-based map of a genome is a powerful tool for genetic studies and is especially useful for the positional cloning and positional candidate approaches. The availability of gene maps for multiple organisms provides the foundation for detailed conserved-orthology maps showing the correspondence between conserved genomic segments. These maps make it possible to use cross-species information in gene hunts and shed light on the evolutionary forces that shape the genome. Here we report a radiation hybrid map of mouse genes, a combined project of the Whitehead Institute/Massachusetts Institute of Technology Center for Genome Research, the Medical Research Council UK Mouse Genome Centre, and the National Center for Biotechnology Information. The map contains 11,109 genes, screened against the T31 RH panel and positioned relative to a reference map containing 2,280 mouse genetic markers. It includes 3,658 genes homologous to the human genome sequence and provides a framework for overlaying the human genome sequence to the mouse and for sequencing the mouse genome.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalNature Genetics
Issue number2
StatePublished - 2001
Externally publishedYes


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