A Quantitative Genetic Interaction Map of HIV Infection

David E. Gordon; Ariane Watson; Assen Roguev; Simin Zheng; Gwendolyn M. Jang; Joshua Kane; Jiewei Xu; Jeffrey Z. Guo; Erica Stevenson; Danielle L. Swaney; Kathy Franks-Skiba; Erik Verschueren; Michael Shales; David C. Crosby; Alan D. Frankel; Alexander Marson; Ivan Marazzi; Gerard Cagney; Nevan J. Krogan

doi:10.1016/j.molcel.2020.02.004

A Quantitative Genetic Interaction Map of HIV Infection

David E. Gordon, Ariane Watson, Assen Roguev, Simin Zheng, Gwendolyn M. Jang, Joshua Kane, Jiewei Xu, Jeffrey Z. Guo, Erica Stevenson, Danielle L. Swaney, Kathy Franks-Skiba, Erik Verschueren, Michael Shales, David C. Crosby, Alan D. Frankel, Alexander Marson, Ivan Marazzi, Gerard Cagney, Nevan J. Krogan

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Most experimental genetic screens studying pathogen infection study one genetic element at a time; however, Gordon et al. adapted epistasis mapping to study combinations of perturbations impacting HIV infection and use their approach to identify and characterize a role for CCR4-NOT in mediating HIV infection.

Original language	English
Pages (from-to)	197-209.e7
Journal	Molecular Cell
Volume	78
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2020.02.004
State	Published - 16 Apr 2020

Keywords

CCR4-NOT
CNOT complex
IRF7
combinatorial genetics
epistasis map
host-pathogen network biology
innate immunity
interferon stimulated gene
vE-MAP
viral infection genetic screen

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Gordon, D. E., Watson, A., Roguev, A., Zheng, S., Jang, G. M., Kane, J., Xu, J., Guo, J. Z., Stevenson, E., Swaney, D. L., Franks-Skiba, K., Verschueren, E., Shales, M., Crosby, D. C., Frankel, A. D., Marson, A., Marazzi, I., Cagney, G., & Krogan, N. J. (2020). A Quantitative Genetic Interaction Map of HIV Infection. Molecular Cell, 78(2), 197-209.e7. https://doi.org/10.1016/j.molcel.2020.02.004

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title = "A Quantitative Genetic Interaction Map of HIV Infection",

abstract = "Most experimental genetic screens studying pathogen infection study one genetic element at a time; however, Gordon et al. adapted epistasis mapping to study combinations of perturbations impacting HIV infection and use their approach to identify and characterize a role for CCR4-NOT in mediating HIV infection.",

keywords = "CCR4-NOT, CNOT complex, IRF7, combinatorial genetics, epistasis map, host-pathogen network biology, innate immunity, interferon stimulated gene, vE-MAP, viral infection genetic screen",

author = "Gordon, {David E.} and Ariane Watson and Assen Roguev and Simin Zheng and Jang, {Gwendolyn M.} and Joshua Kane and Jiewei Xu and Guo, {Jeffrey Z.} and Erica Stevenson and Swaney, {Danielle L.} and Kathy Franks-Skiba and Erik Verschueren and Michael Shales and Crosby, {David C.} and Frankel, {Alan D.} and Alexander Marson and Ivan Marazzi and Gerard Cagney and Krogan, {Nevan J.}",

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year = "2020",

month = apr,

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doi = "10.1016/j.molcel.2020.02.004",

language = "English",

volume = "78",

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Gordon, DE, Watson, A, Roguev, A, Zheng, S, Jang, GM, Kane, J, Xu, J, Guo, JZ, Stevenson, E, Swaney, DL, Franks-Skiba, K, Verschueren, E, Shales, M, Crosby, DC, Frankel, AD, Marson, A, Marazzi, I, Cagney, G & Krogan, NJ 2020, 'A Quantitative Genetic Interaction Map of HIV Infection', Molecular Cell, vol. 78, no. 2, pp. 197-209.e7. https://doi.org/10.1016/j.molcel.2020.02.004

TY - JOUR

T1 - A Quantitative Genetic Interaction Map of HIV Infection

AU - Gordon, David E.

AU - Watson, Ariane

AU - Roguev, Assen

AU - Zheng, Simin

AU - Jang, Gwendolyn M.

AU - Kane, Joshua

AU - Xu, Jiewei

AU - Guo, Jeffrey Z.

AU - Stevenson, Erica

AU - Swaney, Danielle L.

AU - Franks-Skiba, Kathy

AU - Verschueren, Erik

AU - Shales, Michael

AU - Crosby, David C.

AU - Frankel, Alan D.

AU - Marson, Alexander

AU - Marazzi, Ivan

AU - Cagney, Gerard

AU - Krogan, Nevan J.

PY - 2020/4/16

Y1 - 2020/4/16

N2 - Most experimental genetic screens studying pathogen infection study one genetic element at a time; however, Gordon et al. adapted epistasis mapping to study combinations of perturbations impacting HIV infection and use their approach to identify and characterize a role for CCR4-NOT in mediating HIV infection.

AB - Most experimental genetic screens studying pathogen infection study one genetic element at a time; however, Gordon et al. adapted epistasis mapping to study combinations of perturbations impacting HIV infection and use their approach to identify and characterize a role for CCR4-NOT in mediating HIV infection.

KW - CCR4-NOT

KW - CNOT complex

KW - IRF7

KW - combinatorial genetics

KW - epistasis map

KW - host-pathogen network biology

KW - innate immunity

KW - interferon stimulated gene

KW - vE-MAP

KW - viral infection genetic screen

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U2 - 10.1016/j.molcel.2020.02.004

DO - 10.1016/j.molcel.2020.02.004

M3 - Article

C2 - 32084337

AN - SCOPUS:85083007770

SN - 1097-2765

VL - 78

SP - 197-209.e7

JO - Molecular Cell

JF - Molecular Cell

IS - 2

ER -

A Quantitative Genetic Interaction Map of HIV Infection

Abstract

Keywords

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