TY - JOUR
T1 - A prospective study of prenatal and childhood lead exposure and erythropoietin
AU - Graziano, Joseph
AU - Slavkovich, Vesna
AU - Liu, Xin Hua
AU - Factor-Litvak, Pam
AU - Todd, Andrew
PY - 2004/9
Y1 - 2004/9
N2 - We test the hypothesis that chronic lead (Pb) exposure may be associated with an inability to maintain an adequate serum erythropoietin (EPO) concentration. From a longitudinal study of Pb exposure and infant and childhood development, we measured blood Pb (BPb) and serum EPO concentrations serially at ages 4.5, 6.5, 9.5, and 12 and tibia (cortical) Pb concentration at age 12. Pb-exposed children aged 4.5 and 6.5 produced increased concentrations of EPO to maintain normal Hgb concentrations. EPO production declined between ages 4.5 and 6.5. At ages 9.5 and 12, further diminution of the association was found. No association was found between tibia Pb and EPO. The continued decline in the slope of the relationship between EPO and BPb with age, after adjustment for hemoglobin, implies a gradually decreasing capacity to produce EPO.
AB - We test the hypothesis that chronic lead (Pb) exposure may be associated with an inability to maintain an adequate serum erythropoietin (EPO) concentration. From a longitudinal study of Pb exposure and infant and childhood development, we measured blood Pb (BPb) and serum EPO concentrations serially at ages 4.5, 6.5, 9.5, and 12 and tibia (cortical) Pb concentration at age 12. Pb-exposed children aged 4.5 and 6.5 produced increased concentrations of EPO to maintain normal Hgb concentrations. EPO production declined between ages 4.5 and 6.5. At ages 9.5 and 12, further diminution of the association was found. No association was found between tibia Pb and EPO. The continued decline in the slope of the relationship between EPO and BPb with age, after adjustment for hemoglobin, implies a gradually decreasing capacity to produce EPO.
UR - http://www.scopus.com/inward/record.url?scp=4544265607&partnerID=8YFLogxK
U2 - 10.1097/01.jom.0000137721.95544.4f
DO - 10.1097/01.jom.0000137721.95544.4f
M3 - Article
C2 - 15354056
AN - SCOPUS:4544265607
SN - 1076-2752
VL - 46
SP - 924
EP - 929
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 9
ER -