A prospective study of plasma inflammatory markers and risk of colorectal cancer in men

M. Song; K. Wu; S. Ogino; C. S. Fuchs; E. L. Giovannucci; A. T. Chan

doi:10.1038/bjc.2013.172

A prospective study of plasma inflammatory markers and risk of colorectal cancer in men

M. Song
, K. Wu
, S. Ogino
, C. S. Fuchs
, E. L. Giovannucci
, A. T. Chan

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Background: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent. Methods: We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study. Results: Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99-2.40; P_trend =0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78-2.05; P_trend =0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (P_interaction=0. 03). We did not observe any significant association between CRP or sTNFR-2 and CRC. Conclusion: Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.

Original language	English
Pages (from-to)	1891-1898
Number of pages	8
Journal	British Journal of Cancer
Volume	108
Issue number	9
DOIs	https://doi.org/10.1038/bjc.2013.172
State	Published - 14 May 2013
Externally published	Yes

Keywords

Body mass index
C-reactive protein
Colorectal cancer
Interleukin-6
Soluble tumour necrosis factor receptor 2

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10.1038/bjc.2013.172

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@article{492433a033014faa908b9d9417bd1ee6,

title = "A prospective study of plasma inflammatory markers and risk of colorectal cancer in men",

abstract = "Background: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent. Methods: We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study. Results: Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95\% confidence interval (CI), 0.99-2.40; Ptrend =0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95\% CI, 0.78-2.05; Ptrend =0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (Pinteraction=0. 03). We did not observe any significant association between CRP or sTNFR-2 and CRC. Conclusion: Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.",

keywords = "Body mass index, C-reactive protein, Colorectal cancer, Interleukin-6, Soluble tumour necrosis factor receptor 2",

author = "M. Song and K. Wu and S. Ogino and Fuchs, \{C. S.\} and Giovannucci, \{E. L.\} and Chan, \{A. T.\}",

note = "Funding Information: We thank the participants and staff of the Health Professionals Follow-up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. We also thank Xuehong Zhang, ScD, for assistance in programming; and Gary Bradwin and Nader Rifai, PhD, for measurements of the inflammatory analytes. This work was supported by US National Institute of Health Grants, P01 CA55075 (to WC Willett), UM1 CA167552 (to WC Willett), P50 CA127003 (to CSF), R01 CA151993 (to SO), and R01 CA137178 and K24 DK 098311 (to ATC). Dr Andrew T Chan is a Damon Runyon Cancer Foundation Clinical Investigator.",

year = "2013",

month = may,

day = "14",

doi = "10.1038/bjc.2013.172",

language = "English",

volume = "108",

pages = "1891--1898",

journal = "British Journal of Cancer",

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TY - JOUR

T1 - A prospective study of plasma inflammatory markers and risk of colorectal cancer in men

AU - Song, M.

AU - Wu, K.

AU - Ogino, S.

AU - Fuchs, C. S.

AU - Giovannucci, E. L.

AU - Chan, A. T.

N1 - Funding Information: We thank the participants and staff of the Health Professionals Follow-up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. We also thank Xuehong Zhang, ScD, for assistance in programming; and Gary Bradwin and Nader Rifai, PhD, for measurements of the inflammatory analytes. This work was supported by US National Institute of Health Grants, P01 CA55075 (to WC Willett), UM1 CA167552 (to WC Willett), P50 CA127003 (to CSF), R01 CA151993 (to SO), and R01 CA137178 and K24 DK 098311 (to ATC). Dr Andrew T Chan is a Damon Runyon Cancer Foundation Clinical Investigator.

PY - 2013/5/14

Y1 - 2013/5/14

N2 - Background: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent. Methods: We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study. Results: Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99-2.40; Ptrend =0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78-2.05; Ptrend =0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (Pinteraction=0. 03). We did not observe any significant association between CRP or sTNFR-2 and CRC. Conclusion: Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.

AB - Background: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent. Methods: We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study. Results: Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99-2.40; Ptrend =0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78-2.05; Ptrend =0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (Pinteraction=0. 03). We did not observe any significant association between CRP or sTNFR-2 and CRC. Conclusion: Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.

KW - Body mass index

KW - C-reactive protein

KW - Colorectal cancer

KW - Interleukin-6

KW - Soluble tumour necrosis factor receptor 2

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DO - 10.1038/bjc.2013.172

M3 - Article

C2 - 23591192

AN - SCOPUS:84878616260

SN - 0007-0920

VL - 108

SP - 1891

EP - 1898

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 9

ER -

A prospective study of plasma inflammatory markers and risk of colorectal cancer in men

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Keywords

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