@article{d734ffa4a9ea44188aa6c0964498088e,
title = "A prospective study of erythrocyte polyunsaturated fatty acids and risk of colorectal serrated polyps and conventional adenomas",
abstract = "The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n−3 and n−6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts who had provided a blood sample and undergone at least one endoscopic examination. We calculated the multivariable odds ratios (ORs) per 1 SD increment in individual PUFAs and the ratio of n−6/n−3 PUFAs. We considered P <.005 statistically significant to account for multiple testing. During a median of 20 years of follow-up, we documented 493 conventional adenomas and 316 serrated polyps. After adjusting for various CRC risk factors, no associations for PUFAs achieved the stringent statistical significance for either conventional adenomas or serrated polyps (ORs per 1 SD ranged from 0.90 to 1.14). Some associations achieved nominal significance (P <.05), including the association of dihomogammalinolenic acid (DGLA) (20:3, n−6) with lower risk of conventional adenomas (OR = 0.91; 95% confidence interval [CI] = 0.83-1.00), total n−6 PUFAs with higher risk of proximal serrated polyps (OR = 1.32; 95% CI = 1.01-1.74) and eicosadienoic acid (20:2, n−6) and DGLA with lower risk of advanced adenomas (OR = 0.83; 95% CI = 0.71-0.97 and OR = 0.84; 95% CI = 0.72-0.98, respectively). Our findings indicate that erythrocyte PUFAs in a typical American diet are unlikely to have a substantial influence on risk of colorectal cancer precursors. The subgroup associations require further confirmation.",
keywords = "chemoprevention, colonoscopy, fish oil, primary prevention",
author = "Liang Wang and Dong Hang and Xiaosheng He and Lo, {Chun Han} and Kana Wu and Chan, {Andrew T.} and Shuji Ogino and Giovannucci, {Edward L.} and Mingyang Song",
note = "Funding Information: 3&3 Team Project of the First Affiliated Hospital of Sun Yat‐sen University; American Cancer Society, Grant/Award Number: MRSG‐17‐220‐01 ‐ NEC; American Institute for Cancer Research; Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance; The Friends of the Dana‐Farber Cancer Institute; the Project P Fund for Colorectal Cancer Research; U.S. National Institutes of Health, Grant/Award Numbers: K24 DK098311, P01 CA55075, P01 CA87969, R00 CA215314, R01 CA137178, R01 CA151993, R01 CA202704, R01 CA49449, R01 CA67262, R03 CA197879, R21 CA230873, R35 CA197735, U01 CA167552, U01 CA176726, UM1 CA167552, UM1 CA186107 Funding information Funding Information: We would like to thank the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA and WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by the American Cancer Society Mentored Research Scholar Grant (MRSG‐17‐220‐01 ‐ NEC to M. S.) by the U.S. National Institutes of Health (NIH) grants (P01 CA87969 to M. J. Stampfer; UM1 CA186107 to M. J. Stampfer; P01 CA55075 to W. C. Willett; R01 CA49449, R01 CA67262, UM1 CA167552 to W. C. Willett; U01 CA167552 to W. C. Willett and L. A. Mucci; K24 DK098311, R01 CA137178, R01 CA202704, U01 CA176726 to A. T. C.; R01 CA151993, R35 CA197735 to S. O.; R03 CA197879 to K. W.; R21 CA230873 to K. W. and S.O.; R00 CA215314 to M. S.) and by grants from the American Institute for Cancer Research (K.W.), the Project P Fund for Colorectal Cancer Research, The Friends of the Dana‐Farber Cancer Institute, Bennett Family Fund and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. Dr Chan is a Stuart and Suzanne Steele MGH Research Scholar. The funders had no role in design and conduct of the study collection, management, analysis and interpretation of the data and preparation, review or approval of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. L. W. was supported by the “3&3 Team Project” of the First Affiliated Hospital of Sun Yat‐sen University. Funding Information: We would like to thank the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA and WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by the American Cancer Society Mentored Research Scholar Grant (MRSG-17-220-01 - NEC to M. S.) by the U.S. National Institutes of Health (NIH) grants (P01 CA87969 to M. J. Stampfer; UM1 CA186107 to M. J. Stampfer; P01 CA55075 to W. C. Willett; R01 CA49449, R01 CA67262, UM1 CA167552 to W. C. Willett; U01 CA167552 to W. C. Willett and L. A. Mucci; K24 DK098311, R01 CA137178, R01 CA202704, U01 CA176726 to A. T. C.; R01 CA151993, R35 CA197735 to S. O.; R03 CA197879 to K. W.; R21 CA230873 to K. W. and S.O.; R00 CA215314 to M. S.) and by grants from the American Institute for Cancer Research (K.W.), the Project P Fund for Colorectal Cancer Research, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. Dr Chan is a Stuart and Suzanne Steele MGH Research Scholar. The funders had no role in design and conduct of the study collection, management, analysis and interpretation of the data and preparation, review or approval of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. L. W. was supported by the “3&3 Team Project” of the First Affiliated Hospital of Sun Yat-sen University. Publisher Copyright: {\textcopyright} 2020 UICC",
year = "2021",
month = jan,
day = "1",
doi = "10.1002/ijc.33190",
language = "English",
volume = "148",
pages = "57--66",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",
}