TY - JOUR
T1 - A Primer in Precision Nephrology
T2 - Optimizing Outcomes in Kidney Health and Disease through Data-Driven Medicine
AU - Jayaraman, Pushkala
AU - Crouse, Andrew
AU - Nadkarni, Girish
AU - Might, Matthew
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - This year marks the 63rd anniversary of the International Society of Nephrology, which signaled nephrology's emergence as a modern medical discipline. In this article, we briefly trace the course of nephrology's history to show a clear arc in its evolution-of increasing resolution in nephrological data-an arc that is converging with computational capabilities to enable precision nephrology. In general, precision medicine refers to tailoring treatment to the individual characteristics of patients. For an operational definition, this tailoring takes the form of an optimization, in which treatments are selected to maximize a patient's expected health with respect to all available data. Because modern health data are large and high resolution, this optimization process requires computational intervention, and it must be tuned to the contours of specific medical disciplines. An advantage of this operational definition for precision medicine is that it allows us to better understand what precision medicine means in the context of a specific medical discipline. The goal of this article was to demonstrate how to instantiate this definition of precision medicine for the field of nephrology.
AB - This year marks the 63rd anniversary of the International Society of Nephrology, which signaled nephrology's emergence as a modern medical discipline. In this article, we briefly trace the course of nephrology's history to show a clear arc in its evolution-of increasing resolution in nephrological data-an arc that is converging with computational capabilities to enable precision nephrology. In general, precision medicine refers to tailoring treatment to the individual characteristics of patients. For an operational definition, this tailoring takes the form of an optimization, in which treatments are selected to maximize a patient's expected health with respect to all available data. Because modern health data are large and high resolution, this optimization process requires computational intervention, and it must be tuned to the contours of specific medical disciplines. An advantage of this operational definition for precision medicine is that it allows us to better understand what precision medicine means in the context of a specific medical discipline. The goal of this article was to demonstrate how to instantiate this definition of precision medicine for the field of nephrology.
KW - artificial intelligence
KW - data science
KW - genetics
KW - precision medicine
KW - precision nephrology
UR - http://www.scopus.com/inward/record.url?scp=85161722191&partnerID=8YFLogxK
U2 - 10.34067/KID.0000000000000089
DO - 10.34067/KID.0000000000000089
M3 - Review article
AN - SCOPUS:85161722191
SN - 2641-7650
VL - 4
SP - E544-E554
JO - Kidney360
JF - Kidney360
IS - 4
ER -