TY - JOUR
T1 - A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression
AU - Serretti, Alessandro
AU - Chiesa, Alberto
AU - Calati, Raffaella
AU - Massat, Isabelle
AU - Linotte, Sylvie
AU - Kasper, Siegfried
AU - Lecrubier, Yves
AU - Antonijevic, Irina
AU - Forray, Carlos
AU - Snyder, Lenore
AU - Bollen, Joseph
AU - Zohar, Joseph
AU - De Ronchi, Diana
AU - Souery, Daniel
AU - Mendlewicz, Julien
PY - 2011/1
Y1 - 2011/1
N2 - Background: The transcription factor Cyclic adenosine monophosphate Response Element Binding (CREB) protein has been repeatedly involved in the aetiology and pharmacotherapy of major depression (MD). The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants. Methods: One hundred-ninety MD patients collected in the context of a resistant depression study and treated with antidepressants for at least 4 weeks were genotyped for 5 CREB1 SNPs (rs2709376, rs2253206, rs7569963, rs7594560, and rs4675690). Response, remission and treatment resistance were recorded. Results: An allele of rs7569963 as well as rs2253206-rs7569963 A-A and rs7569963-rs4675690 A-C haplotypes were associated with the status of treatment resistance. Additionally, rs7569963 GG genotype was positively associated with remission. No further significant associations were observed. Limitations: Limitations of the present study include a relatively small sample size and the incomplete ascertainment of data which could influence the outcome. Conclusions: Our results preliminary suggest that some genetic polymorphisms in CREB1 could be associated to treatment resistance. Although such finding needs to be replicated in larger samples, it increases current knowledge about the genetic predictors of response to antidepressants that will probably lead to enhance treatment outcomes by addressing each individual to the most appropriate treatment strategy in the early stages of treatment.
AB - Background: The transcription factor Cyclic adenosine monophosphate Response Element Binding (CREB) protein has been repeatedly involved in the aetiology and pharmacotherapy of major depression (MD). The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants. Methods: One hundred-ninety MD patients collected in the context of a resistant depression study and treated with antidepressants for at least 4 weeks were genotyped for 5 CREB1 SNPs (rs2709376, rs2253206, rs7569963, rs7594560, and rs4675690). Response, remission and treatment resistance were recorded. Results: An allele of rs7569963 as well as rs2253206-rs7569963 A-A and rs7569963-rs4675690 A-C haplotypes were associated with the status of treatment resistance. Additionally, rs7569963 GG genotype was positively associated with remission. No further significant associations were observed. Limitations: Limitations of the present study include a relatively small sample size and the incomplete ascertainment of data which could influence the outcome. Conclusions: Our results preliminary suggest that some genetic polymorphisms in CREB1 could be associated to treatment resistance. Although such finding needs to be replicated in larger samples, it increases current knowledge about the genetic predictors of response to antidepressants that will probably lead to enhance treatment outcomes by addressing each individual to the most appropriate treatment strategy in the early stages of treatment.
KW - CREB1
KW - Major depression
KW - Remission
KW - Response
KW - Treatment resistance
UR - https://www.scopus.com/pages/publications/78649655526
U2 - 10.1016/j.jad.2010.06.025
DO - 10.1016/j.jad.2010.06.025
M3 - Article
C2 - 20643483
AN - SCOPUS:78649655526
SN - 0165-0327
VL - 128
SP - 56
EP - 63
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-2
ER -