A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

Hu Xu; Shuaijie Song; Jing Zhao; Chao Liang Leng; Jun Fu; Chao Li; Yan dong Tang; Lirun Xiang; Jinmei Peng; Qian Wang; Hongyuan Zhao; Tongqing An; Xue Hui Cai; Hong Liang Zhang; Zhi Jun Tian

doi:10.1111/tbed.13508

A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

Hu Xu, Shuaijie Song, Jing Zhao, Chao Liang Leng, Jun Fu, Chao Li, Yan dong Tang, Lirun Xiang, Jinmei Peng, Qian Wang, Hongyuan Zhao, Tongqing An, Xue Hui Cai, Hong Liang Zhang, Zhi Jun Tian

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Abstract

Porcine respiratory and reproductive syndrome virus (PRRSV) causes an economically important disease affecting commercial pork production worldwide. NADC34-like PRRSV has had a strong impact on the U.S. and Peruvian pig industries in recent years and also emerged in northeastern China in 2017. However, the endemic status of NADC34-like PRRSV in China is unclear. In this study, we examined 650 tissue samples collected from 16 Provinces in China from 2018 to 2019. Six NADC34-like PRRSV strains were detected in samples from three Provinces, and the complete genomes of four of these strains were sequenced. Phylogenetic analysis showed that these novel PRRSV strains belong to sublineage 1.5 (or NADC34-like PRRSV), forming two groups in China. Sequence alignment suggested that these novel strains share the same 100-aa deletion in the Nsp2 protein that was identified in IA/2014/NADC34 isolated from the United States in 2014. Recombination analysis revealed that five of eight complete genome sequences are derived from recombination between IA/2014/NADC34 and ISU30 or NADC30. The number and distribution of NADC34-like PRRSVs is increasing in China. Importantly, compared with the currently endemic strain NADC30-like PRRSV, NADC34-like PRRSV has the potential to be an endemic strain in China. This study will help us understand the epidemic status of NADC34-like PRRSV in China and provide data for further monitoring this type of PRRSV in China.

Original language	English
Pages (from-to)	1730-1738
Number of pages	9
Journal	Transboundary and Emerging Diseases
Volume	67
Issue number	4
DOIs	https://doi.org/10.1111/tbed.13508
State	Published - 1 Jul 2020
Externally published	Yes

Keywords

NADC34-like
PRRSV
potential endemic strain

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10.1111/tbed.13508

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title = "A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus",

abstract = "Porcine respiratory and reproductive syndrome virus (PRRSV) causes an economically important disease affecting commercial pork production worldwide. NADC34-like PRRSV has had a strong impact on the U.S. and Peruvian pig industries in recent years and also emerged in northeastern China in 2017. However, the endemic status of NADC34-like PRRSV in China is unclear. In this study, we examined 650 tissue samples collected from 16 Provinces in China from 2018 to 2019. Six NADC34-like PRRSV strains were detected in samples from three Provinces, and the complete genomes of four of these strains were sequenced. Phylogenetic analysis showed that these novel PRRSV strains belong to sublineage 1.5 (or NADC34-like PRRSV), forming two groups in China. Sequence alignment suggested that these novel strains share the same 100-aa deletion in the Nsp2 protein that was identified in IA/2014/NADC34 isolated from the United States in 2014. Recombination analysis revealed that five of eight complete genome sequences are derived from recombination between IA/2014/NADC34 and ISU30 or NADC30. The number and distribution of NADC34-like PRRSVs is increasing in China. Importantly, compared with the currently endemic strain NADC30-like PRRSV, NADC34-like PRRSV has the potential to be an endemic strain in China. This study will help us understand the epidemic status of NADC34-like PRRSV in China and provide data for further monitoring this type of PRRSV in China.",

keywords = "NADC34-like, PRRSV, potential endemic strain",

author = "Hu Xu and Shuaijie Song and Jing Zhao and Leng, {Chao Liang} and Jun Fu and Chao Li and Tang, {Yan dong} and Lirun Xiang and Jinmei Peng and Qian Wang and Hongyuan Zhao and Tongqing An and Cai, {Xue Hui} and Zhang, {Hong Liang} and Tian, {Zhi Jun}",

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day = "1",

doi = "10.1111/tbed.13508",

language = "English",

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T1 - A potential endemic strain in China

T2 - NADC34‑like porcine reproductive and respiratory syndrome virus

AU - Xu, Hu

AU - Song, Shuaijie

AU - Zhao, Jing

AU - Leng, Chao Liang

AU - Fu, Jun

AU - Li, Chao

AU - Tang, Yan dong

AU - Xiang, Lirun

AU - Peng, Jinmei

AU - Wang, Qian

AU - Zhao, Hongyuan

AU - An, Tongqing

AU - Cai, Xue Hui

AU - Zhang, Hong Liang

AU - Tian, Zhi Jun

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Porcine respiratory and reproductive syndrome virus (PRRSV) causes an economically important disease affecting commercial pork production worldwide. NADC34-like PRRSV has had a strong impact on the U.S. and Peruvian pig industries in recent years and also emerged in northeastern China in 2017. However, the endemic status of NADC34-like PRRSV in China is unclear. In this study, we examined 650 tissue samples collected from 16 Provinces in China from 2018 to 2019. Six NADC34-like PRRSV strains were detected in samples from three Provinces, and the complete genomes of four of these strains were sequenced. Phylogenetic analysis showed that these novel PRRSV strains belong to sublineage 1.5 (or NADC34-like PRRSV), forming two groups in China. Sequence alignment suggested that these novel strains share the same 100-aa deletion in the Nsp2 protein that was identified in IA/2014/NADC34 isolated from the United States in 2014. Recombination analysis revealed that five of eight complete genome sequences are derived from recombination between IA/2014/NADC34 and ISU30 or NADC30. The number and distribution of NADC34-like PRRSVs is increasing in China. Importantly, compared with the currently endemic strain NADC30-like PRRSV, NADC34-like PRRSV has the potential to be an endemic strain in China. This study will help us understand the epidemic status of NADC34-like PRRSV in China and provide data for further monitoring this type of PRRSV in China.

AB - Porcine respiratory and reproductive syndrome virus (PRRSV) causes an economically important disease affecting commercial pork production worldwide. NADC34-like PRRSV has had a strong impact on the U.S. and Peruvian pig industries in recent years and also emerged in northeastern China in 2017. However, the endemic status of NADC34-like PRRSV in China is unclear. In this study, we examined 650 tissue samples collected from 16 Provinces in China from 2018 to 2019. Six NADC34-like PRRSV strains were detected in samples from three Provinces, and the complete genomes of four of these strains were sequenced. Phylogenetic analysis showed that these novel PRRSV strains belong to sublineage 1.5 (or NADC34-like PRRSV), forming two groups in China. Sequence alignment suggested that these novel strains share the same 100-aa deletion in the Nsp2 protein that was identified in IA/2014/NADC34 isolated from the United States in 2014. Recombination analysis revealed that five of eight complete genome sequences are derived from recombination between IA/2014/NADC34 and ISU30 or NADC30. The number and distribution of NADC34-like PRRSVs is increasing in China. Importantly, compared with the currently endemic strain NADC30-like PRRSV, NADC34-like PRRSV has the potential to be an endemic strain in China. This study will help us understand the epidemic status of NADC34-like PRRSV in China and provide data for further monitoring this type of PRRSV in China.

KW - NADC34-like

KW - PRRSV

KW - potential endemic strain

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VL - 67

SP - 1730

EP - 1738

JO - Transboundary and Emerging Diseases

JF - Transboundary and Emerging Diseases

IS - 4

ER -

A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

Abstract

Keywords

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