A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis

Nikhil Dhingra; Emma Guttman-Yassky

doi:10.1038/jid.2014.141

A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis

Nikhil Dhingra
, Emma Guttman-Yassky

Research output: Contribution to journal › Comment/debate

48 Scopus citations

Abstract

Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.

Original language	English
Pages (from-to)	2071-2074
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	134
Issue number	8
DOIs	https://doi.org/10.1038/jid.2014.141
State	Published - Aug 2014

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title = "A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis",

abstract = "Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.",

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N2 - Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.

AB - Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.

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JF - Journal of Investigative Dermatology

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ER -

A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis

Abstract

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