TY - JOUR
T1 - A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
AU - Dhingra, Nikhil
AU - Guttman-Yassky, Emma
PY - 2014/8
Y1 - 2014/8
N2 - Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.
AB - Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.
UR - http://www.scopus.com/inward/record.url?scp=84904410851&partnerID=8YFLogxK
U2 - 10.1038/jid.2014.141
DO - 10.1038/jid.2014.141
M3 - Comment/debate
C2 - 25029321
AN - SCOPUS:84904410851
SN - 0022-202X
VL - 134
SP - 2071
EP - 2074
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 8
ER -