A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women

Diana Puente; Patricia Hartge; Eberhard Greiser; Kenneth P. Cantor; Will D. King; Carlos A. González; Sylvaine Cordier; Paolo Vineis; Elsebeth Lynge; Jenny Chang-Claude; Stefano Porru; Anastasia Tzonou; Karl Heinz Jöckel; Consol Serra; Martine Hours; Charles F. Lynch; Ulrich Ranft; Jürgen Wahrendorf; Debra Silverman; Francisco Fernandez; Paolo Boffetta; Manolis Kogevinas

doi:10.1007/s10552-005-0389-0

A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women

Diana Puente, Patricia Hartge, Eberhard Greiser, Kenneth P. Cantor, Will D. King, Carlos A. González, Sylvaine Cordier, Paolo Vineis, Elsebeth Lynge, Jenny Chang-Claude, Stefano Porru, Anastasia Tzonou, Karl Heinz Jöckel, Consol Serra, Martine Hours, Charles F. Lynch, Ulrich Ranft, Jürgen Wahrendorf, Debra Silverman, Francisco FernandezPaolo Boffetta, Manolis Kogevinas

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Objective: A recent study suggested that risk of bladder cancer may be higher in women than in men who smoked comparable amounts of cigarettes. We pooled primary data from 14 case-control studies of bladder cancer from Europe and North America and evaluated differences in risk of smoking by gender. Methods: The pooled analysis included 8316 cases (21% women) and 17,406 controls (28% women) aged 30-79 years. Odds ratios (ORs) and 95% confidence intervals (95% CI) for smoking were adjusted for age and study. Exposure-response was evaluated in a stratified analysis by gender and by generalized additive models. Results: The odds ratios for current smokers compared to nonsmokers were 3.9 (95% CI 3.5-4.3) for males and 3.6 (3.1-4.1) for females. In 11 out of 14 studies, ORs were slightly higher in men. ORs for current smoking were similar for men (OR = 3.4) and women (OR = 3.7) in North America, while in Europe men (OR = 5.3) had higher ORs than women (OR = 3.9). ORs increased with duration and intensity in both genders and the exposure-response patterns were remarkably similar between genders. Conclusion: These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men.

Original language	English
Pages (from-to)	71-79
Number of pages	9
Journal	Cancer Causes and Control
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/s10552-005-0389-0
State	Published - Feb 2006
Externally published	Yes

Keywords

Bladder cancer
Case-control studies
Gender differences
Pooled analysis
Tobacco smoke

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10.1007/s10552-005-0389-0

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Puente, D., Hartge, P., Greiser, E., Cantor, K. P., King, W. D., González, C. A., Cordier, S., Vineis, P., Lynge, E., Chang-Claude, J., Porru, S., Tzonou, A., Jöckel, K. H., Serra, C., Hours, M., Lynch, C. F., Ranft, U., Wahrendorf, J., Silverman, D., ... Kogevinas, M. (2006). A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women. Cancer Causes and Control, 17(1), 71-79. https://doi.org/10.1007/s10552-005-0389-0

@article{ddcb53bdd9524ca8831b2887e5bc5bba,

title = "A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women",

abstract = "Objective: A recent study suggested that risk of bladder cancer may be higher in women than in men who smoked comparable amounts of cigarettes. We pooled primary data from 14 case-control studies of bladder cancer from Europe and North America and evaluated differences in risk of smoking by gender. Methods: The pooled analysis included 8316 cases (21% women) and 17,406 controls (28% women) aged 30-79 years. Odds ratios (ORs) and 95% confidence intervals (95% CI) for smoking were adjusted for age and study. Exposure-response was evaluated in a stratified analysis by gender and by generalized additive models. Results: The odds ratios for current smokers compared to nonsmokers were 3.9 (95% CI 3.5-4.3) for males and 3.6 (3.1-4.1) for females. In 11 out of 14 studies, ORs were slightly higher in men. ORs for current smoking were similar for men (OR = 3.4) and women (OR = 3.7) in North America, while in Europe men (OR = 5.3) had higher ORs than women (OR = 3.9). ORs increased with duration and intensity in both genders and the exposure-response patterns were remarkably similar between genders. Conclusion: These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men.",

keywords = "Bladder cancer, Case-control studies, Gender differences, Pooled analysis, Tobacco smoke",

author = "Diana Puente and Patricia Hartge and Eberhard Greiser and Cantor, {Kenneth P.} and King, {Will D.} and Gonz{\'a}lez, {Carlos A.} and Sylvaine Cordier and Paolo Vineis and Elsebeth Lynge and Jenny Chang-Claude and Stefano Porru and Anastasia Tzonou and J{\"o}ckel, {Karl Heinz} and Consol Serra and Martine Hours and Lynch, {Charles F.} and Ulrich Ranft and J{\"u}rgen Wahrendorf and Debra Silverman and Francisco Fernandez and Paolo Boffetta and Manolis Kogevinas",

note = "Funding Information: Funding: The study was partly supported by grant SOC 96-200742 05F02 of the Europe Against Cancer programme, and DG SANCO Project 2001/CAN/112 of the European Commission; by a grant by the Generalitat (Government) of Catalunya (DURSI 2001/SGR/ 00406); and by grants (01/1326E and G03/173) of the Fondo de In-vestigaci{\'o}n Sanitaria, Ministry of Education, Spain. M Kogevinas was partly funded by a visiting scientist award at the DCEG, NCI, Bethesda.",

year = "2006",

month = feb,

doi = "10.1007/s10552-005-0389-0",

language = "English",

volume = "17",

pages = "71--79",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

number = "1",

}

Puente, D, Hartge, P, Greiser, E, Cantor, KP, King, WD, González, CA, Cordier, S, Vineis, P, Lynge, E, Chang-Claude, J, Porru, S, Tzonou, A, Jöckel, KH, Serra, C, Hours, M, Lynch, CF, Ranft, U, Wahrendorf, J, Silverman, D, Fernandez, F, Boffetta, P & Kogevinas, M 2006, 'A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women', Cancer Causes and Control, vol. 17, no. 1, pp. 71-79. https://doi.org/10.1007/s10552-005-0389-0

TY - JOUR

T1 - A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women

AU - Puente, Diana

AU - Hartge, Patricia

AU - Greiser, Eberhard

AU - Cantor, Kenneth P.

AU - King, Will D.

AU - González, Carlos A.

AU - Cordier, Sylvaine

AU - Vineis, Paolo

AU - Lynge, Elsebeth

AU - Chang-Claude, Jenny

AU - Porru, Stefano

AU - Tzonou, Anastasia

AU - Jöckel, Karl Heinz

AU - Serra, Consol

AU - Hours, Martine

AU - Lynch, Charles F.

AU - Ranft, Ulrich

AU - Wahrendorf, Jürgen

AU - Silverman, Debra

AU - Fernandez, Francisco

AU - Boffetta, Paolo

AU - Kogevinas, Manolis

N1 - Funding Information: Funding: The study was partly supported by grant SOC 96-200742 05F02 of the Europe Against Cancer programme, and DG SANCO Project 2001/CAN/112 of the European Commission; by a grant by the Generalitat (Government) of Catalunya (DURSI 2001/SGR/ 00406); and by grants (01/1326E and G03/173) of the Fondo de In-vestigación Sanitaria, Ministry of Education, Spain. M Kogevinas was partly funded by a visiting scientist award at the DCEG, NCI, Bethesda.

PY - 2006/2

Y1 - 2006/2

N2 - Objective: A recent study suggested that risk of bladder cancer may be higher in women than in men who smoked comparable amounts of cigarettes. We pooled primary data from 14 case-control studies of bladder cancer from Europe and North America and evaluated differences in risk of smoking by gender. Methods: The pooled analysis included 8316 cases (21% women) and 17,406 controls (28% women) aged 30-79 years. Odds ratios (ORs) and 95% confidence intervals (95% CI) for smoking were adjusted for age and study. Exposure-response was evaluated in a stratified analysis by gender and by generalized additive models. Results: The odds ratios for current smokers compared to nonsmokers were 3.9 (95% CI 3.5-4.3) for males and 3.6 (3.1-4.1) for females. In 11 out of 14 studies, ORs were slightly higher in men. ORs for current smoking were similar for men (OR = 3.4) and women (OR = 3.7) in North America, while in Europe men (OR = 5.3) had higher ORs than women (OR = 3.9). ORs increased with duration and intensity in both genders and the exposure-response patterns were remarkably similar between genders. Conclusion: These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men.

AB - Objective: A recent study suggested that risk of bladder cancer may be higher in women than in men who smoked comparable amounts of cigarettes. We pooled primary data from 14 case-control studies of bladder cancer from Europe and North America and evaluated differences in risk of smoking by gender. Methods: The pooled analysis included 8316 cases (21% women) and 17,406 controls (28% women) aged 30-79 years. Odds ratios (ORs) and 95% confidence intervals (95% CI) for smoking were adjusted for age and study. Exposure-response was evaluated in a stratified analysis by gender and by generalized additive models. Results: The odds ratios for current smokers compared to nonsmokers were 3.9 (95% CI 3.5-4.3) for males and 3.6 (3.1-4.1) for females. In 11 out of 14 studies, ORs were slightly higher in men. ORs for current smoking were similar for men (OR = 3.4) and women (OR = 3.7) in North America, while in Europe men (OR = 5.3) had higher ORs than women (OR = 3.9). ORs increased with duration and intensity in both genders and the exposure-response patterns were remarkably similar between genders. Conclusion: These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men.

KW - Bladder cancer

KW - Case-control studies

KW - Gender differences

KW - Pooled analysis

KW - Tobacco smoke

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U2 - 10.1007/s10552-005-0389-0

DO - 10.1007/s10552-005-0389-0

M3 - Article

C2 - 16411055

AN - SCOPUS:30544439626

SN - 0957-5243

VL - 17

SP - 71

EP - 79

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 1

ER -

A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women

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Keywords

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