A polypill strategy to improve global secondary cardiovascular prevention: From concept to reality

José M. Castellano, Ginés Sanz, Antonio Fernandez Ortiz, Ester Garrido, Sameer Bansilal, Valentin Fuster

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


The prevention of cardiovascular disease (CVD) by using a polypill has gained increasing momentum as a strategy to contain progression of the disease. Since its initial conception just over a decade ago, only a handful of trials have been completed assessing the efficacy and safety of this innovative concept. The results of these trials have supported the viability of the polypill in CVD prevention and management, albeit with a few caveats, essentially related to the lack of evidence on the effect of the polypill to effectively reduce cardiovascular events. The polypill has the potential to control the global health epidemic of CVD by effectively reaching underdeveloped regions of the world, simplifying healthcare delivery, improving cost-effectiveness, increasing medication adherence, and supporting a comprehensive prescription of evidence-based cardioprotective drugs. Major trials underway will provide definitive evidence on the efficacy of the polypill in reducing cardiovascular events in a cost-effective manner. The results of these studies will determine whether a polypill strategy can quell the burgeoning public health challenge of CVD and will potentially provide the evidence to implement an effective, simple, and innovative solution to restrain the global CVD pandemic.

Original languageEnglish
Pages (from-to)613-621
Number of pages9
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - 12 Aug 2014


  • cardiovascular disease
  • fixed-dose combination
  • global cardiovascular health
  • polypill
  • secondary prevention


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