A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Catherine Kelly, Caroline Trumpff, Carlos Acosta, Stephanie Assuras, Jack Baker, Sophia Basarrate, Alexander Behnke, Ke Bo, Natalia Bobba-Alves, Frances A. Champagne, Quinn Conklin, Marissa Cross, Philip De Jager, Kris Engelstad, Elissa Epel, Soah G. Franklin, Michio Hirano, Qiuhan Huang, Alex Junker, Robert Paul JusterDarshana Kapri, Clemens Kirschbaum, Mangesh Kurade, Vincenzo Lauriola, Shufang Li, Cynthia C. Liu, Grace Liu, Bruce McEwen, Marlon A. McGill, Kathleen McIntyre, Anna S. Monzel, Jeremy Michelson, Aric A. Prather, Eli Puterman, Xiomara Q. Rosales, Peter A. Shapiro, David Shire, George M. Slavich, Richard P. Sloan, Janell L.M. Smith, Marisa Spann, Julie Spicer, Gabriel Sturm, Sophia Tepler, Michel Thiebaut de Schotten, Tor D. Wager, Martin Picard

Research output: Contribution to journalReview articlepeer-review

Abstract

Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain–body, and mind–mitochondria processes relevant to medicine and public health.

Original languageEnglish
Pages (from-to)884-901
Number of pages18
JournalTrends in Endocrinology and Metabolism
Volume35
Issue number10
DOIs
StatePublished - Oct 2024

Keywords

  • allostasis
  • metabolism
  • mitochondrial disorders
  • mtDNA
  • psychobiology
  • stress

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