A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

Lena S. Andersen; Jessica F. Magidson; Conall O’Cleirigh; Jessica E. Remmert; Ashraf Kagee; Matthew Leaver; Dan J. Stein; Steven A. Safren; John Joska

doi:10.1177/1359105316643375

A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

Lena S. Andersen
, Jessica F. Magidson
, Conall O’Cleirigh
, Jessica E. Remmert
, Ashraf Kagee
, Matthew Leaver
, Dan J. Stein
, Steven A. Safren
, John Joska

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa (n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.

Original language	English
Pages (from-to)	776-787
Number of pages	12
Journal	Journal of Health Psychology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1177/1359105316643375
State	Published - 1 May 2018
Externally published	Yes

Keywords

HIV
South Africa
adherence
cognitive behavioral therapy
depression
low- and middle-income countries
task-sharing

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10.1177/1359105316643375

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Andersen, L. S., Magidson, J. F., O’Cleirigh, C., Remmert, J. E., Kagee, A., Leaver, M., Stein, D. J., Safren, S. A., & Joska, J. (2018). A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa. Journal of Health Psychology, 23(6), 776-787. https://doi.org/10.1177/1359105316643375

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abstract = "Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa (n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.",

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AU - Magidson, Jessica F.

AU - O’Cleirigh, Conall

AU - Remmert, Jessica E.

AU - Kagee, Ashraf

AU - Leaver, Matthew

AU - Stein, Dan J.

AU - Safren, Steven A.

AU - Joska, John

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AB - Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa (n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.

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A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

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Keywords

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