A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana

Lawrence H. Yang; Evan L. Eschliman; Haitisha Mehta; Supriya Misra; Ohemaa B. Poku; Patlo Entaile; Timothy D. Becker; Tadele Melese; Merrian J. Brooks; Marlene Eisenberg; Melissa A. Stockton; Karen Choe; Danielle Tal; Tingyu Li; Vivian F. Go; Bruce G. Link; Shathani Rampa; Valerie W. Jackson; Gorata D. Manyeagae; Tonya Arscott-Mills; Melody Goodman; Philip R. Opondo; Ari R. Ho-Foster; Michael B. Blank

doi:10.1186/s12981-022-00454-3

A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana

Lawrence H. Yang, Evan L. Eschliman, Haitisha Mehta, Supriya Misra, Ohemaa B. Poku, Patlo Entaile, Timothy D. Becker, Tadele Melese, Merrian J. Brooks, Marlene Eisenberg, Melissa A. Stockton, Karen Choe, Danielle Tal, Tingyu Li, Vivian F. Go, Bruce G. Link, Shathani Rampa, Valerie W. Jackson, Gorata D. Manyeagae, Tonya Arscott-MillsMelody Goodman, Philip R. Opondo, Ari R. Ho-Foster, Michael B. Blank

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We conducted a pilot trial of an intervention targeting intersectional stigma related to being pregnant and living with HIV while promoting capabilities for achieving ‘respected motherhood’ (‘what matters most’) in Botswana. A pragmatic design allocated participants to the intervention (N = 44) group and the treatment-as-usual (N = 15) group. An intent-to-treat, difference-in-difference analysis found the intervention group had significant decreases in HIV stigma (d = − 1.20; 95% CI − 1.99, − 0.39) and depressive symptoms (d = − 1.96; 95% CI − 2.89, − 1.02) from baseline to 4-months postpartum. Some, albeit less pronounced, changes in intersectional stigma were observed, suggesting the importance of structural-level intervention components to reduce intersectional stigma.

Original language	English
Article number	26
Journal	AIDS Research and Therapy
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12981-022-00454-3
State	Published - Dec 2022

Keywords

Botswana
Culture
Intersectional stigma
Pregnant women living with HIV
Stigma intervention

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10.1186/s12981-022-00454-3

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Yang, L. H., Eschliman, E. L., Mehta, H., Misra, S., Poku, O. B., Entaile, P., Becker, T. D., Melese, T., Brooks, M. J., Eisenberg, M., Stockton, M. A., Choe, K., Tal, D., Li, T., Go, V. F., Link, B. G., Rampa, S., Jackson, V. W., Manyeagae, G. D., ... Blank, M. B. (2022). A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana. AIDS Research and Therapy, 19(1), Article 26. https://doi.org/10.1186/s12981-022-00454-3

@article{e8a98a4c9eed4f01a8b29b5aab790040,

title = "A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana",

abstract = "We conducted a pilot trial of an intervention targeting intersectional stigma related to being pregnant and living with HIV while promoting capabilities for achieving {\textquoteleft}respected motherhood{\textquoteright} ({\textquoteleft}what matters most{\textquoteright}) in Botswana. A pragmatic design allocated participants to the intervention (N = 44) group and the treatment-as-usual (N = 15) group. An intent-to-treat, difference-in-difference analysis found the intervention group had significant decreases in HIV stigma (d = − 1.20; 95% CI − 1.99, − 0.39) and depressive symptoms (d = − 1.96; 95% CI − 2.89, − 1.02) from baseline to 4-months postpartum. Some, albeit less pronounced, changes in intersectional stigma were observed, suggesting the importance of structural-level intervention components to reduce intersectional stigma.",

keywords = "Botswana, Culture, Intersectional stigma, Pregnant women living with HIV, Stigma intervention",

author = "Yang, {Lawrence H.} and Eschliman, {Evan L.} and Haitisha Mehta and Supriya Misra and Poku, {Ohemaa B.} and Patlo Entaile and Becker, {Timothy D.} and Tadele Melese and Brooks, {Merrian J.} and Marlene Eisenberg and Stockton, {Melissa A.} and Karen Choe and Danielle Tal and Tingyu Li and Go, {Vivian F.} and Link, {Bruce G.} and Shathani Rampa and Jackson, {Valerie W.} and Manyeagae, {Gorata D.} and Tonya Arscott-Mills and Melody Goodman and Opondo, {Philip R.} and Ho-Foster, {Ari R.} and Blank, {Michael B.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s12981-022-00454-3",

language = "English",

volume = "19",

journal = "AIDS Research and Therapy",

issn = "1742-6405",

publisher = "BioMed Central Ltd.",

number = "1",

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Yang, LH, Eschliman, EL, Mehta, H, Misra, S, Poku, OB, Entaile, P, Becker, TD, Melese, T, Brooks, MJ, Eisenberg, M, Stockton, MA, Choe, K, Tal, D, Li, T, Go, VF, Link, BG, Rampa, S, Jackson, VW, Manyeagae, GD, Arscott-Mills, T, Goodman, M, Opondo, PR, Ho-Foster, AR & Blank, MB 2022, 'A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana', AIDS Research and Therapy, vol. 19, no. 1, 26. https://doi.org/10.1186/s12981-022-00454-3

TY - JOUR

T1 - A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana

AU - Yang, Lawrence H.

AU - Eschliman, Evan L.

AU - Mehta, Haitisha

AU - Misra, Supriya

AU - Poku, Ohemaa B.

AU - Entaile, Patlo

AU - Becker, Timothy D.

AU - Melese, Tadele

AU - Brooks, Merrian J.

AU - Eisenberg, Marlene

AU - Stockton, Melissa A.

AU - Choe, Karen

AU - Tal, Danielle

AU - Li, Tingyu

AU - Go, Vivian F.

AU - Link, Bruce G.

AU - Rampa, Shathani

AU - Jackson, Valerie W.

AU - Manyeagae, Gorata D.

AU - Arscott-Mills, Tonya

AU - Goodman, Melody

AU - Opondo, Philip R.

AU - Ho-Foster, Ari R.

AU - Blank, Michael B.

PY - 2022/12

Y1 - 2022/12

N2 - We conducted a pilot trial of an intervention targeting intersectional stigma related to being pregnant and living with HIV while promoting capabilities for achieving ‘respected motherhood’ (‘what matters most’) in Botswana. A pragmatic design allocated participants to the intervention (N = 44) group and the treatment-as-usual (N = 15) group. An intent-to-treat, difference-in-difference analysis found the intervention group had significant decreases in HIV stigma (d = − 1.20; 95% CI − 1.99, − 0.39) and depressive symptoms (d = − 1.96; 95% CI − 2.89, − 1.02) from baseline to 4-months postpartum. Some, albeit less pronounced, changes in intersectional stigma were observed, suggesting the importance of structural-level intervention components to reduce intersectional stigma.

AB - We conducted a pilot trial of an intervention targeting intersectional stigma related to being pregnant and living with HIV while promoting capabilities for achieving ‘respected motherhood’ (‘what matters most’) in Botswana. A pragmatic design allocated participants to the intervention (N = 44) group and the treatment-as-usual (N = 15) group. An intent-to-treat, difference-in-difference analysis found the intervention group had significant decreases in HIV stigma (d = − 1.20; 95% CI − 1.99, − 0.39) and depressive symptoms (d = − 1.96; 95% CI − 2.89, − 1.02) from baseline to 4-months postpartum. Some, albeit less pronounced, changes in intersectional stigma were observed, suggesting the importance of structural-level intervention components to reduce intersectional stigma.

KW - Botswana

KW - Culture

KW - Intersectional stigma

KW - Pregnant women living with HIV

KW - Stigma intervention

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U2 - 10.1186/s12981-022-00454-3

DO - 10.1186/s12981-022-00454-3

M3 - Article

C2 - 35739534

AN - SCOPUS:85132566101

SN - 1742-6405

VL - 19

JO - AIDS Research and Therapy

JF - AIDS Research and Therapy

IS - 1

M1 - 26

ER -

A pilot pragmatic trial of a “what matters most”-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana

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Keywords

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