TY - JOUR
T1 - A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD
AU - Cantor, Jerome
AU - Ma, Shuren
AU - Turino, Gerard
N1 - Publisher Copyright:
© 2017 Cantor et al.
PY - 2017/9/18
Y1 - 2017/9/18
N2 - A novel therapy for COPD involving the use of aerosolized hyaluronan (HA) was tested on a small cohort of COPD patients to determine both its safety and efficacy in reducing levels of desmosine and isodesmosine (DID), biomarkers for elastin degradation. In a 2-week, randomized, double-blind trial, 8 patients receiving 150 kDa HA (mean molecular weight) and 3 others given placebo did not show significant adverse effects with regard to spirometry, electrocardiograms, and hematological indices. Furthermore, measurements of DID in plasma from HA-treated patients indicated a progressive decrease over a 3-week period following initiation of treatment (r=-0.98; p=0.02), whereas patients receiving placebo showed no reduction in DID (r=-0.70; p=0.30). Measurements of sputum in the HA-treated group also revealed a progressive decrease in DID (r=-0.97; p=0.03), but this finding was limited by the absence of similar measurements in the placebo group. Nevertheless, the results of this small, pilot study support a longer-term trial of HA in a larger population of COPD patients.
AB - A novel therapy for COPD involving the use of aerosolized hyaluronan (HA) was tested on a small cohort of COPD patients to determine both its safety and efficacy in reducing levels of desmosine and isodesmosine (DID), biomarkers for elastin degradation. In a 2-week, randomized, double-blind trial, 8 patients receiving 150 kDa HA (mean molecular weight) and 3 others given placebo did not show significant adverse effects with regard to spirometry, electrocardiograms, and hematological indices. Furthermore, measurements of DID in plasma from HA-treated patients indicated a progressive decrease over a 3-week period following initiation of treatment (r=-0.98; p=0.02), whereas patients receiving placebo showed no reduction in DID (r=-0.70; p=0.30). Measurements of sputum in the HA-treated group also revealed a progressive decrease in DID (r=-0.97; p=0.03), but this finding was limited by the absence of similar measurements in the placebo group. Nevertheless, the results of this small, pilot study support a longer-term trial of HA in a larger population of COPD patients.
KW - COPD
KW - Desmosine
KW - Elastin
KW - Hyaluronan
UR - http://www.scopus.com/inward/record.url?scp=85030213640&partnerID=8YFLogxK
U2 - 10.2147/COPD.S142156
DO - 10.2147/COPD.S142156
M3 - Article
C2 - 29075107
AN - SCOPUS:85030213640
SN - 1176-9106
VL - 12
SP - 2747
EP - 2752
JO - International Journal of COPD
JF - International Journal of COPD
ER -