A phase I clinical study of a serological test for detection of leukemia-associated antigens (LAA)

Marilyn S. Pollack, Joseph E. Sokal, Yashar Hirshaut, Elias Cohen, Carl Feit, Michael Gimbol, John E. Fitzpatrick

Research output: Contribution to journalArticlepeer-review


A series of antisera to leukemia-associated antigens (LAA) were prepared by immunization of monkeys and rabbits with leukemia cells or leukemia cell extracts and absorption of the resultant antisera with red blood cells and leukocytes from healthy donors. These antisera were used with a complement-dependent microcytotoxicity test procedure at two leukemia treatment centers in a controlled Phase I clinical study designed to evaluate the specificity and sensitivity of the antisera for the detection of LAA and the suitability of the test procedure for routine clinical use. Tests of mononuclear cells prepared from coded blood samples of patients with different types of leukemia in various stages, patients with other malignancies and benign disorders unrelated to leukemia, and healthy controls indicated that several antisera had sufficient specificity and sensitivity for the detection of LAA to be of potential clinical value. These studies also suggested that such antisera might be useful in monitoring patients with leukemia and evaluating the quality of disease control, although the test procedure had some disadvantages for routine use in a general hematology laboratory.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalLeukemia Research
Issue number4
StatePublished - 1978
Externally publishedYes


  • Leukemia-associated antigens
  • blastic crisis
  • cytotoxicity test
  • leukemia


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