A phase 3 trial of l-glutamine in sickle cell disease

Yutaka Niihara, Scott T. Miller, Julie Kanter, Sophie Lanzkron, Wally R. Smith, Lewis L. Hsu, Victor R. Gordeuk, Kusum Viswanathan, Sharada Sarnaik, Ifeyinwa Osunkwo, Edouard Guillaume, Swayam Sadanandan, Lance Sieger, Joseph L. Lasky, Eduard H. Panosyan, Osbourne A. Blake, Tamara N. New, Rita Bellevue, Lan T. Tran, Rafael L. RazonCharles W. Stark, Lynne D. Neumayr, Elliott P. Vichinsky

Research output: Contribution to journalArticlepeer-review

334 Scopus citations


BACKGROUND Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been shown to increase the proportion of the reduced form of nicotinamide adenine dinucleotides in sickle cell erythrocytes, which probably reduces oxidative stress and could result in fewer episodes of sickle cell-related pain. METHODS In a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial, we tested the efficacy of pharmaceutical-grade l-glutamine (0.3 g per kilogram of body weight per dose) administered twice daily by mouth, as compared with placebo, in reducing the incidence of pain crises among patients with sickle cell anemia or sickle β0-thalassemia and a history of two or more pain crises during the previous year. Patients who were receiving hydroxyurea at a dose that had been stable for at least 3 months before screening continued that therapy through the 48-week treatment period. RESULTS A total of 230 patients (age range, 5 to 58 years; 53.9% female) were randomly assigned, in a 2:1 ratio, to receive l-glutamine (152 patients) or placebo (78 patients). The patients in the l-glutamine group had significantly fewer pain crises than those in the placebo group (P = 0.005), with a median of 3.0 in the l-glutamine group and 4.0 in the placebo group. Fewer hospitalizations occurred in the l-glutamine group than in the placebo group (P = 0.005), with a median of 2.0 in the l-glutamine group and 3.0 in the placebo group. Two thirds of the patients in both trial groups received concomitant hydroxyurea. Low-grade nausea, noncardiac chest pain, fatigue, and musculoskeletal pain occurred more frequently in the l-glutamine group than in the placebo group. CONCLUSIONS Among children and adults with sickle cell anemia, the median number of pain crises over 48 weeks was lower among those who received oral therapy with l-glutamine, administered alone or with hydroxyurea, than among those who received placebo, with or without hydroxyurea. (Funded by Emmaus Medical; ClinicalTrials.gov number, NCT01179217.)

Original languageEnglish
Pages (from-to)226-235
Number of pages10
JournalNew England Journal of Medicine
Issue number3
StatePublished - 19 Jul 2018
Externally publishedYes


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