A perspective on sympathetic renal denervation in chronic congestive heart failure

Raef Madanieh, Mohammed El-Hunjul, Hassan Alkhawam, Constantine E. Kosmas, Abed Madanieh, Timothy J. Vittorio

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Medical therapy has indisputably been the mainstay of management for chronic congestive heart failure. However, a significant percentage of patients continue to experience worsening heart failure (HF) symptoms despite treatment with multiple therapeutic agents. Recently, catheter-based interventional strategies that interrupt the renal sympathetic nervous system have shown promising results in providing better symptom control in patients with HF. In this article, we will review the pathophysiology of HF for better understanding of the interplay between the cardiovascular system and the kidney. Subsequently, we will briefly discuss pivotal renal denervation (RDN) therapy trials in patients with resistant hypertension and then present the available evidence on the role of RDN in HF therapy.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalHeart Failure Reviews
Issue number1
StatePublished - 1 Jan 2016


  • Heart failure
  • Renal denervation
  • Sympathetic nervous system


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