A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish

Nan Yang; Zhenyu Yue

doi:10.1016/j.tins.2017.12.001

A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish

Nan Yang, Zhenyu Yue

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.

Original language	English
Pages (from-to)	74-76
Number of pages	3
Journal	Trends in Neurosciences
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.tins.2017.12.001
State	Published - Feb 2018

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title = "A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish",

abstract = "Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.",

author = "Nan Yang and Zhenyu Yue",

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AU - Yang, Nan

AU - Yue, Zhenyu

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N2 - Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.

AB - Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.

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U2 - 10.1016/j.tins.2017.12.001

DO - 10.1016/j.tins.2017.12.001

M3 - Short survey

C2 - 29248177

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EP - 76

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 2

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A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish

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