A patient with persistent pruritus

Lawrence U. Liu, Lihui Qin, A. S. Knisely

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


We present a patient with an initial and acute presentation of jaundice and marked persistent pruritus. Laboratory and radiology test results eliminated the possibility of acute hepatitis A/B/C viral infections, primary biliary cirrhosis, autoimmune hepatitis, Wilson disease, paraneoplastic cholestasis, and obstructive biliary disease. Centrilobular cholestasis was prominent in a liver biopsy specimen. Benign recurrent intrahepatic cholestasis (BRIC) was diagnosed through a review of the clinical history, available data, and the subsequent exclusion of other possible etiologies. The patient's clinical features resolved within 3 months of medical treatment.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalSeminars in Liver Disease
Issue number2
StatePublished - 2010


  • Cholestasis
  • Jaundice
  • Recurrent pruritus


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