A patient with chronic hepatitis B and regression of fibrosis during treatment

Charissa Y. Chang, Paul Martin, Anastasia Fotiadu, Prodromos Hytiroglou

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


We present a patient with HBeAg-negative chronic hepatitis B, in whom significant regression of hepatic fibrosis was achieved after a lengthy antiviral treatment. A liver biopsy specimen obtained at initiation of treatment showed chronic hepatitis B with mild activity (histologic activity index: 7) and marked fibrosis (stage 4, in a scale of 0 to 6). A second biopsy specimen, obtained 10 years later, demonstrated almost complete resolution of necroinflammatory activity and fibrosis. One year after the second biopsy, seroconversion from HBsAg positive to anti-HBs positive status was achieved, and antiviral treatment was discontinued. This case is illustrative of the significant histologic improvement that can be accomplished in chronic hepatitis B when viral activity is suppressed long term. Lengthy antiviral treatment can achieve resorption of excess fibrous tissue, even in patients with marked fibrosis.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalSeminars in Liver Disease
Issue number3
StatePublished - 2010


  • Chronic hepatitis B
  • HBsAg seroconversion
  • regression of fibrosis


Dive into the research topics of 'A patient with chronic hepatitis B and regression of fibrosis during treatment'. Together they form a unique fingerprint.

Cite this