A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia

Katsuya Yamamoto; Atsuo Okamura; Kanako Wakahashi; Yoshio Katayama; Manabu Shimoyama; Toshimitsu Matsui

doi:10.1016/j.cancergencyto.2010.02.006

A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia

Katsuya Yamamoto, Atsuo Okamura, Kanako Wakahashi, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We describe here a novel unbalanced whole-arm translocation der(3;10)(q10;q10) in a 58-year-old man with acute monocytic leukemia. Bone marrow was massively infiltrated with 22.2% monoblasts, 55.4% promonocytes, and 5.6% monocytes. These monocytic cells were positive for myeloperoxidase and α-naphthyl butyrate esterase staining. Surface marker analysis revealed that they were positive for CD4, CD13, CD33, CD56, and HLA-DR but negative for CD14 and CD34. Chromosome analysis of the bone marrow cells showed 46,XY,+3,der(3;10)(q10;q10)[18]/46,XY[2]. Spectral karyotyping confirmed der(3;10)(q10;q10) as a sole structural abnormality. By acquisition of a normal chromosome 3 but not a chromosome 10, the der(3;10)(q10;q10) resulted in trisomy 3q and monosomy 10p. The +3,der(3;10)(q10;q10) is thought to play a crucial role in the pathogenesis of acute monocytic leukemia because of the gain of 3q or the loss of 10p.

Original language	English
Pages (from-to)	134-138
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	199
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2010.02.006
State	Published - Jun 2010
Externally published	Yes

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title = "A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia",

abstract = "We describe here a novel unbalanced whole-arm translocation der(3;10)(q10;q10) in a 58-year-old man with acute monocytic leukemia. Bone marrow was massively infiltrated with 22.2% monoblasts, 55.4% promonocytes, and 5.6% monocytes. These monocytic cells were positive for myeloperoxidase and α-naphthyl butyrate esterase staining. Surface marker analysis revealed that they were positive for CD4, CD13, CD33, CD56, and HLA-DR but negative for CD14 and CD34. Chromosome analysis of the bone marrow cells showed 46,XY,+3,der(3;10)(q10;q10)[18]/46,XY[2]. Spectral karyotyping confirmed der(3;10)(q10;q10) as a sole structural abnormality. By acquisition of a normal chromosome 3 but not a chromosome 10, the der(3;10)(q10;q10) resulted in trisomy 3q and monosomy 10p. The +3,der(3;10)(q10;q10) is thought to play a crucial role in the pathogenesis of acute monocytic leukemia because of the gain of 3q or the loss of 10p.",

author = "Katsuya Yamamoto and Atsuo Okamura and Kanako Wakahashi and Yoshio Katayama and Manabu Shimoyama and Toshimitsu Matsui",

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AU - Shimoyama, Manabu

AU - Matsui, Toshimitsu

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AB - We describe here a novel unbalanced whole-arm translocation der(3;10)(q10;q10) in a 58-year-old man with acute monocytic leukemia. Bone marrow was massively infiltrated with 22.2% monoblasts, 55.4% promonocytes, and 5.6% monocytes. These monocytic cells were positive for myeloperoxidase and α-naphthyl butyrate esterase staining. Surface marker analysis revealed that they were positive for CD4, CD13, CD33, CD56, and HLA-DR but negative for CD14 and CD34. Chromosome analysis of the bone marrow cells showed 46,XY,+3,der(3;10)(q10;q10)[18]/46,XY[2]. Spectral karyotyping confirmed der(3;10)(q10;q10) as a sole structural abnormality. By acquisition of a normal chromosome 3 but not a chromosome 10, the der(3;10)(q10;q10) resulted in trisomy 3q and monosomy 10p. The +3,der(3;10)(q10;q10) is thought to play a crucial role in the pathogenesis of acute monocytic leukemia because of the gain of 3q or the loss of 10p.

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A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia

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