A recent paper by Fang et al. examined the role of Agouti-Related Peptide (AgRP)-expressing neurons in the arcuate nucleus of the hypothalamus in mediating depressive-like behavior in mice. Chronic, but not acute stress, led to changes in neuronal excitability in AgRP neurons concomitant with the display of depressive-like behaviors, which were bidirectionally modulated using AgRP-selective chemogenetic manipulations. Together, these findings broaden our understanding of the diverse roles AgRP neurons play in driving motivational states, aside from their influence on hunger and feeding behaviors.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalTrends in Neurosciences
Issue number4
StatePublished - Apr 2021


  • chemogenetics
  • chronic stress
  • depression
  • electrophysiology
  • neuronal excitability
  • synaptic plasticity


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