Abstract
Background: Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied. Methods: Nintey-six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue. Results: The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PD patients from controls on Cirrus, 57% on RTVue. Conclusion: Parkinson's disease shallows the superior/inferior and to a lesser degree nasal-temporal foveal slope. The symmetry, breadth, and depth model fits optical coherence tomography data derived from two different devices, and it is proposed as a diagnostic tool in PD.
| Original language | English |
|---|---|
| Pages (from-to) | 1692-1695 |
| Number of pages | 4 |
| Journal | Movement Disorders |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| State | Published - Oct 2015 |
| Externally published | Yes |
Keywords
- Foveal pit
- Optical coherence tomography
- Parkinson's disease
- Principal component analysis
- SBD model
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