A novel mutation of the hGR gene causing Chrousos syndrome

Keyphrases

• Glucocorticoid Receptor Gene 100%
• Novel mutation 100%
• Human Glucocorticoid Receptor 100%
• Chrousos Syndrome 100%
• Glucocorticoid Signaling 66%
• Natural mutant 66%
• Molecular Mechanism 33%
• Arginine 33%
• Histidine 33%
• Hirsutism 33%
• Clinical Manifestations 33%
• Receptor-interacting Protein Kinase 1 (RIPK1) 33%
• Adrenocorticotropic Hormone 33%
• Three-dimensional (3D) 33%
• Nuclear factor-B 33%
• Glucocorticoid Receptor 33%
• Coactivator 33%
• Helix 33%
• Acne 33%
• Low Affinity 33%
• Androstenedione 33%
• Responsive Genes 33%
• Multiple Steps 33%
• Alopecia 33%
• Cushing's Syndrome 33%
• Nuclear Translocation 33%
• Serum Cortisol 33%
• Irregular Menstrual Cycle 33%
• Amino Acid Position 33%
• Natural mutation 33%
• Urinary Free Cortisol 33%
• B Signaling Pathway 33%
• Activation Function 33%
• Molecular Modeling Studies 33%
• Cortisol Excretion 33%
• Tissue Susceptibility 33%
• NR3C1 Gene 33%
• Structural Shifts 33%

Biochemistry, Genetics and Molecular Biology

• Receptor Gene 100%
• Glucocorticoid Receptor 100%
• Glucocorticoid 100%
• Signal Transduction 60%
• Wild Type 20%
• Amino Acids 20%
• Molecular Model 20%
• Complement Factor B 20%
• Target Tissue 20%
• Menstrual Cycle 20%
• Adrenocorticotropic Hormone 20%
• Rigidity 20%
• Androstenedione Blood Level 20%
• Hydrocortisone Blood Level 20%
• Nuclear Receptor Coactivator 2 20%
• Blood Plasma 20%
• Histidine 20%
• Arginine 20%
• Cortisol 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Syndrome 100%
• Receptor 100%
• Glucocorticoid Receptor 100%
• Glucocorticoid 71%
• Hydrocortisone 28%
• Hirsutism 14%
• Corticotropin 14%
• Amino Acid 14%
• Acne 14%
• Arginine 14%
• Androstenedione 14%
• Histidine 14%
• Alopecia 14%
• Alternative Complement Pathway C3 C5 Convertase 14%
• Nuclear Factor 14%
• Cushing Syndrome 14%
• Nuclear Receptor Coactivator 2 14%