A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma

Keyphrases

• Head-and-neck Squamous Cell Carcinoma (HNSCC) 100%
• Novel mutation 100%
• Cell Growth Inhibition 100%
• LKB1 Gene 100%
• Serine Threonine Kinase 11 100%
• Liver Kinase B1 (LKB1) 40%
• Oncogenesis 20%
• Point mutation 20%
• RPMI 2650 Cells 20%
• Polymorphism 10%
• Exon 10%
• Kinase Activity 10%
• Genetic Modification 10%
• Genome Sequencing 10%
• Gene Function 10%
• Tumor Suppressor Gene 10%
• Cell Growth 10%
• Loss of Heterozygosity 10%
• Reintroduction 10%
• Kinase Domain 10%
• Threonine 10%
• Amino Acid Substitution 10%
• Mutation Frequency 10%
• Gene Expression Vectors 10%
• RPMI 2650 10%

Immunology and Microbiology

• Squamous Cell 100%
• Growth Inhibition 100%
• Neck 100%
• Cell Growth 100%
• Serine 100%
• Threonine 100%
• Wild Type 18%
• Point Mutation 18%
• Exon 9%
• Gene Expression 9%
• Gene Mutation 9%
• Heterozygosity 9%
• Gene Function 9%
• Tumor Suppressor Gene 9%
• Expression Vector 9%
• Amino Acid Substitution 9%
• Mutation Rate 9%
• Missense Mutation 9%
• Genome Sequencing 9%
• RPMI-2650 Cell Line 9%
• Alanine 9%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Growth Inhibition 100%
• Cell Growth 100%
• Serine 100%
• Threonine 100%
• Carcinogenesis 16%
• Wild Type 16%
• Point Mutation 16%
• Exon 8%
• Gene Mutation 8%
• Gene Expression 8%
• Missense Mutation 8%
• Gene Function 8%
• Mutation Rate 8%
• Loss of Heterozygosity 8%
• Tumor Suppressor Gene 8%
• Genome Sequencing 8%
• Amino Acid Substitution 8%
• Expression Vector 8%
• Alanine 8%