A novel method to measure venular perivascular spaces in patients with MS on 7T MRI

I. C. George; A. Arrighi-Allisan; B. N. Delman; P. Balchandani; S. Horng; R. Feldman

doi:10.3174/ajnr.A7144

A novel method to measure venular perivascular spaces in patients with MS on 7T MRI

I. C. George, A. Arrighi-Allisan, B. N. Delman, P. Balchandani, S. Horng, R. Feldman

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.

Original language	English
Pages (from-to)	1069-1072
Number of pages	4
Journal	American Journal of Neuroradiology
Volume	42
Issue number	6
DOIs	https://doi.org/10.3174/ajnr.A7144
State	Published - 1 Jun 2021

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abstract = "In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.",

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AU - Arrighi-Allisan, A.

AU - Delman, B. N.

AU - Balchandani, P.

AU - Horng, S.

AU - Feldman, R.

PY - 2021/6/1

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N2 - In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.

AB - In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.

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A novel method to measure venular perivascular spaces in patients with MS on 7T MRI

Abstract

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