A novel cyp1a1 gene polymorphism in african-americans

Frances Crofts; Greg N. Cosma; Diane Currie; Emanuela Taioli; Paolo Toniolo; Seymour J. Garte

doi:10.1093/carcin/14.9.1729

A novel cyp1a1 gene polymorphism in african-americans

Frances Crofts
, Greg N. Cosma
, Diane Currie
, Emanuela Taioli
, Paolo Toniolo
, Seymour J. Garte

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region ̃300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene.

Original language	English
Pages (from-to)	1729-1731
Number of pages	3
Journal	Carcinogenesis
Volume	14
Issue number	9
DOIs	https://doi.org/10.1093/carcin/14.9.1729
State	Published - Sep 1993
Externally published	Yes

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@article{0e18ff2d28c34813a1e6cee1312b714e,

title = "A novel cyp1a1 gene polymorphism in african-americans",

abstract = "A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region{\~ }300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene.",

author = "Frances Crofts and Cosma, \{Greg N.\} and Diane Currie and Emanuela Taioli and Paolo Toniolo and Garte, \{Seymour J.\}",

note = "Funding Information: The authors thank Frances Mastrota for technical assistance and Mary Bader for typing the manuscript. This work was supported by NIH grants ES04895, ES00260 and CA13343.",

year = "1993",

month = sep,

doi = "10.1093/carcin/14.9.1729",

language = "English",

volume = "14",

pages = "1729--1731",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "9",

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TY - JOUR

T1 - A novel cyp1a1 gene polymorphism in african-americans

AU - Crofts, Frances

AU - Cosma, Greg N.

AU - Currie, Diane

AU - Taioli, Emanuela

AU - Toniolo, Paolo

AU - Garte, Seymour J.

N1 - Funding Information: The authors thank Frances Mastrota for technical assistance and Mary Bader for typing the manuscript. This work was supported by NIH grants ES04895, ES00260 and CA13343.

PY - 1993/9

Y1 - 1993/9

N2 - A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region ̃300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene.

AB - A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region ̃300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene.

UR - https://www.scopus.com/pages/publications/0027364894

U2 - 10.1093/carcin/14.9.1729

DO - 10.1093/carcin/14.9.1729

M3 - Article

C2 - 8104732

AN - SCOPUS:0027364894

SN - 0143-3334

VL - 14

SP - 1729

EP - 1731

JO - Carcinogenesis

JF - Carcinogenesis

IS - 9

ER -

A novel cyp1a1 gene polymorphism in african-americans

Abstract

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