@article{b69fa43b00fd497193e202e6d54678d3,
title = "A novel class of ion displacement ligands as antagonists of the αiIbβ3 receptor that limit conformational reorganization of the receptor",
abstract = "A collection of αIIbβ3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles highlight the potential of these small molecule ion displacement ligands as attractive candidates for clinical development.",
keywords = "Ion displacement ligand, Platelet, αIIbβ3 Integrin receptor",
author = "Jiang, {Jian Kang} and McCoy, {Joshua G.} and Min Shen and LeClair, {Christopher A.} and Wenwei Huang and Ana Negri and Jihong Li and Robert Blue and Harrington, {Amanda Weil} and Sarasija Naini and George David and Choi, {Won Seok} and Elisabetta Volpi and Joseph Fernandez and Mariana Babayeva and Nedelman, {Mark A.} and Marta Filizola and Coller, {Barry S.} and Thomas, {Craig J.}",
note = "Funding Information: The authors thank Jim Bougie, Thomas Daniel and William Leister for compound purification, as well as Paul Shinn, Danielle VanLeer for assistance with compound management. This research was supported by the Molecular Libraries Initiative of the National Institutes of Health Roadmap for Medical Research Grant U54HG005033 and the Intramural Research Program of the National Human Genome Research Institute at the National Institutes of Health . This work was further supported, in part, by Grants HL19278 , HL13629 , and HL48675 , from the National Heart, Lung, and Blood Institute , and CTSA Grant ULRR024143 from the National Center for Advancing Translational Research NIH . Computations were run, in part, on resources available through the Scientific Computing Facility at Icahn School of Medicine at Mount Sinai and in part on TeraGrid advanced computing resources provided by Texas Advanced Computing Center through TG-MCB080077 . ",
year = "2014",
month = feb,
day = "15",
doi = "10.1016/j.bmcl.2013.12.122",
language = "English",
volume = "24",
pages = "1148--1153",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "4",
}