A novel and convenient synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles: useful intermediates for the solid-phase synthesis of 4,5-diarylisoxazoles

Jeffrey J. Letourneau; Christopher Riviello; Michael H.J. Ohlmeyer

doi:10.1016/j.tetlet.2007.01.040

A novel and convenient synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles: useful intermediates for the solid-phase synthesis of 4,5-diarylisoxazoles

Jeffrey J. Letourneau
, Christopher Riviello
, Michael H.J. Ohlmeyer

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A novel synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles employing a [3+2] cycloaddition of a nitrile N-oxide with 2-aryl-1-bromoalkynes as the key step is described. The utility of these 5-aryl-4-bromo-3-carboxyisoxazoles in the solid-phase synthesis of 4,5-diarylisoxazoles is demonstrated.

Original language	English
Pages (from-to)	1739-1743
Number of pages	5
Journal	Tetrahedron Letters
Volume	48
Issue number	10
DOIs	https://doi.org/10.1016/j.tetlet.2007.01.040
State	Published - 5 Mar 2007
Externally published	Yes

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10.1016/j.tetlet.2007.01.040

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title = "A novel and convenient synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles: useful intermediates for the solid-phase synthesis of 4,5-diarylisoxazoles",

abstract = "A novel synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles employing a [3+2] cycloaddition of a nitrile N-oxide with 2-aryl-1-bromoalkynes as the key step is described. The utility of these 5-aryl-4-bromo-3-carboxyisoxazoles in the solid-phase synthesis of 4,5-diarylisoxazoles is demonstrated.",

author = "Letourneau, \{Jeffrey J.\} and Christopher Riviello and Ohlmeyer, \{Michael H.J.\}",

year = "2007",

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doi = "10.1016/j.tetlet.2007.01.040",

language = "English",

volume = "48",

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journal = "Tetrahedron Letters",

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number = "10",

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T1 - A novel and convenient synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles

T2 - useful intermediates for the solid-phase synthesis of 4,5-diarylisoxazoles

AU - Letourneau, Jeffrey J.

AU - Riviello, Christopher

AU - Ohlmeyer, Michael H.J.

PY - 2007/3/5

Y1 - 2007/3/5

N2 - A novel synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles employing a [3+2] cycloaddition of a nitrile N-oxide with 2-aryl-1-bromoalkynes as the key step is described. The utility of these 5-aryl-4-bromo-3-carboxyisoxazoles in the solid-phase synthesis of 4,5-diarylisoxazoles is demonstrated.

AB - A novel synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles employing a [3+2] cycloaddition of a nitrile N-oxide with 2-aryl-1-bromoalkynes as the key step is described. The utility of these 5-aryl-4-bromo-3-carboxyisoxazoles in the solid-phase synthesis of 4,5-diarylisoxazoles is demonstrated.

UR - https://www.scopus.com/pages/publications/33846828583

U2 - 10.1016/j.tetlet.2007.01.040

DO - 10.1016/j.tetlet.2007.01.040

M3 - Article

AN - SCOPUS:33846828583

SN - 0040-4039

VL - 48

SP - 1739

EP - 1743

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 10

ER -

A novel and convenient synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles: useful intermediates for the solid-phase synthesis of 4,5-diarylisoxazoles

Abstract

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