Regional left ventricular dysfunction (asynergy) can be detected by a noninvasive scintiphotographic technic. After intravenous injection of radionuclide (technetium-99m-albumin) electrocardiographically controlled cardiac images (scintiphotographs) are obtained in end-systole and in end-diastole with an Anger scintillation camera. By superimposition of end-systolic and end-diastolic traced images, an assessment of left ventricular wall contraction can be made, and the extent of wall movement quantified. The changes in scintiphotographic ventricular dimensions correlate well with measurements obtained with contrast cineangiography. Eleven patients with ventricular dysfunction were studied by scintiphotographic and contrast radiographic technics. In eight of these, a localized area of impaired left ventricular contraction was demonstrated by both methods. This noninvasive technic appears to offer a safe and repeatable means for assessing regional left ventricular function. The hemodynamic importance of regional myocardial dysfunction (ventricular asynergy) as a cause of cardiac decompensation has recently been emphasized.1 2 3 Although left ventricular (LV) asynergy, particularly ventricular aneurysm, may he suspected clinically, cardiac catheterization and contrast angiography have hitherto been required for defining the presence and extent of abnormality.4 This requirement has limited evaluation of regional myocardial dysfunction to a relatively small number of cardiac patients. The present report details our initial experience with a noninvasive scintiphotographic technic for directly assessing regional myocardial function. This method entails intravenous injection of radionuclide and electrocardiographically controlled cardiac imaging with the use of an.