Abstract
SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.
Original language | English |
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Pages (from-to) | 138-141 |
Number of pages | 4 |
Journal | DNA Repair |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - 5 Jan 2006 |
Keywords
- DNA damage response
- SMC
- SUMO ligase