Abstract

SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalDNA Repair
Volume5
Issue number1
DOIs
StatePublished - 5 Jan 2006

Keywords

  • DNA damage response
  • SMC
  • SUMO ligase

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