A new once-daily formulation of tolterodine provides superior efficacy and is well tolerated in women with overactive bladder

S. Swift, A. Garely, T. Dimpfl, C. Payne

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

This study evaluated the efficacy and tolerability of new extended-release (ER) tolterodine for the treatment of overactive bladder in women. In this subpopulation analysis of a double-blind multicenter trial, 1235 female patients were randomized to oral therapy with tolterodine ER 4 mg once daily (n = 417), tolterodine IR 2 mg twice daily (n = 408) or placebo (n = 410) for 12 weeks. Both formulations reduced the mean number of urge incontinence episodes per week (both P = 0.001 vs placebo); tolterodine ER was more effective than tolterodine IR (P = 0.036). Both formulations significantly improved all other micturition chart variables compared to placebo. Dry mouth was the most common adverse event. There were no safety concerns. Toltrodine ER 4 mg once daily is effective and well tolerated in the treatment of women with overactive bladder, and reduces urge incontinence episodes more than the existing IR twice-daily formulation.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalInternational Urogynecology Journal
Volume14
Issue number1
DOIs
StatePublished - Feb 2003
Externally publishedYes

Keywords

  • Antimuscarinic agents
  • Females
  • Overactive bladder
  • Tolterodine
  • Urge incontinence

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