A New, Objective, Quantitative Scale for Measuring Local Skin Responses Following Topical Actinic Keratosis Therapy with Ingenol Mebutate

Robert Rosen, Ellen Marmur, Lawrence Anderson, Peter Welburn, Janelle Katsamas

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Introduction: Local skin responses (LSRs) are the most common adverse effects of topical actinic keratosis (AK) therapy. There is currently no method available that allows objective characterization of LSRs. Here, the authors describe a new scale developed to quantitatively and objectively assess the six most common LSRs resulting from topical AK therapy with ingenol mebutate.

Methods: The LSR grading scale was developed using a 0–4 numerical rating, with clinical descriptors and representative photographic images for each rating. Good inter-observer grading concordance was demonstrated in peer review during development of the tool. Data on the use of the scale are described from four phase III double-blind studies of ingenol mebutate (n = 1,005).

Results: LSRs peaked on days 4 (face/scalp) or 8 (trunk/extremities), with mean maximum composite LSR scores of 9.1 and 6.8, respectively, and a rapid return toward baseline by day 15 in most cases. Mean composite LSR score at day 57 was generally lower than at baseline.

Conclusion: The LSR grading scale is an objective tool allowing practicing dermatologists to characterize and compare LSRs to existing and, potentially, future AK therapies.

Original languageEnglish
Pages (from-to)207-219
Number of pages13
JournalDermatology and Therapy
Volume4
Issue number2
DOIs
StatePublished - Dec 2014

Keywords

  • Actinic keratosis
  • Dermatology
  • Ingenol mebutate
  • Local skin response
  • Quantitative scale
  • Severity assessment
  • Treatment outcome

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