A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose from 18F-labeled acetyl hypofluorite

C. Y. Shiue; P. A. Salvadori; A. P. Wolf; J. S. Fowler; R. R. MacGregor

A new improved synthesis of 2-deoxy-2-[¹⁸F]fluoro-D-glucose from ¹⁸F-labeled acetyl hypofluorite

C. Y. Shiue
, P. A. Salvadori
, A. P. Wolf
, J. S. Fowler
, R. R. MacGregor

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

A new improved synthesis of 2-deoxy-2-[¹⁸F]fluoro-D-glucose (2-¹⁸FDG,4) from ¹⁸F-labeled acetyl hypofluorite is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal with 1, generated in situ from [¹⁸F]F₂ and ammonium acetate in acetic acid solution at room temperature, gave 2-deoxy-2-[¹⁸F]fluoro-1,3,4,6-tetra-O-acetyl-α-D-glucopyranose. Hydrolysis of compound 3 with 2N HCl gave 2-deoxy-2-[¹⁸F]fluoro-D-glucose in radiochemical yields of ~20% in a synthesis time of 70 min from EOB.

Original language	English
Pages (from-to)	899-903
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	23
Issue number	10
State	Published - 1982

Cite this

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title = "A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose from 18F-labeled acetyl hypofluorite",

abstract = "A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (2-18FDG,4) from 18F-labeled acetyl hypofluorite is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal with 1, generated in situ from [18F]F2 and ammonium acetate in acetic acid solution at room temperature, gave 2-deoxy-2-[18F]fluoro-1,3,4,6-tetra-O-acetyl-α-D-glucopyranose. Hydrolysis of compound 3 with 2N HCl gave 2-deoxy-2-[18F]fluoro-D-glucose in radiochemical yields of \textasciitilde{}20\% in a synthesis time of 70 min from EOB.",

author = "Shiue, \{C. Y.\} and Salvadori, \{P. A.\} and Wolf, \{A. P.\} and Fowler, \{J. S.\} and MacGregor, \{R. R.\}",

year = "1982",

language = "English",

volume = "23",

pages = "899--903",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

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TY - JOUR

T1 - A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose from 18F-labeled acetyl hypofluorite

AU - Shiue, C. Y.

AU - Salvadori, P. A.

AU - Wolf, A. P.

AU - Fowler, J. S.

AU - MacGregor, R. R.

PY - 1982

Y1 - 1982

N2 - A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (2-18FDG,4) from 18F-labeled acetyl hypofluorite is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal with 1, generated in situ from [18F]F2 and ammonium acetate in acetic acid solution at room temperature, gave 2-deoxy-2-[18F]fluoro-1,3,4,6-tetra-O-acetyl-α-D-glucopyranose. Hydrolysis of compound 3 with 2N HCl gave 2-deoxy-2-[18F]fluoro-D-glucose in radiochemical yields of ~20% in a synthesis time of 70 min from EOB.

AB - A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (2-18FDG,4) from 18F-labeled acetyl hypofluorite is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal with 1, generated in situ from [18F]F2 and ammonium acetate in acetic acid solution at room temperature, gave 2-deoxy-2-[18F]fluoro-1,3,4,6-tetra-O-acetyl-α-D-glucopyranose. Hydrolysis of compound 3 with 2N HCl gave 2-deoxy-2-[18F]fluoro-D-glucose in radiochemical yields of ~20% in a synthesis time of 70 min from EOB.

UR - https://www.scopus.com/pages/publications/0019954703

M3 - Article

C2 - 7119884

AN - SCOPUS:0019954703

SN - 0161-5505

VL - 23

SP - 899

EP - 903

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 10

ER -

A new improved synthesis of 2-deoxy-2-[18F]fluoro-D-glucose from 18F-labeled acetyl hypofluorite

Abstract

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A new improved synthesis of 2-deoxy-2-[¹⁸F]fluoro-D-glucose from ¹⁸F-labeled acetyl hypofluorite