A new hemodynamic index to predict late right failure in patients implanted with last generation centrifugal pump

Andrea Montalto, Cristiano Amarelli, Vito Piazza, Kali Hopkins, Marina Comisso, Romina Pantanella, Francesco Musumeci

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Right ventricular failure (RVF) is a severe event that increases perioperative mortality after left ventricle assist device (LVAD) implantation. Right ventricular (RV) function is particularly affected by the LVAD speed by altering RV preload and afterload as well as the position of the interventricular septum. However, there are no studies focusing on the relationship between pump speed optimization and risk factors for the development of late RVF. Methods: Between 2015 and 2019, 50 patients received LVAD implantation at San Camillo Hospital in Rome. Of these, 38 who underwent pump speed optimization were included. Post-optimization hemodynamic data were collected. We assessed a new Hemodynamic Index (HI), calculated as follows: (Formula presented.), to determine the risk of late RVF, which was defined as the requirement for rehospitalization and inotropic support. Results: Ten patients had late RVF after LVAD implantation. Five patients required diuretic therapy and speed optimization. Three patients required inotropic support with adrenaline 0.05 μg/kg/min. Two patients needed prolonged continuous venovenous hemofiltration and high dose inotropic support. Multivariate analysis revealed that a low HI (odds ratio 11.5, 95% confidence interval, 1.85–65.5, p [.003]) was an independent risk factor for late RVF after LVAD implantation. Conclusion: We demonstrated a low HI being a significant risk factor for the development of RVF after LVAD implantation. We suggest implementing HI as a decision support tool for goal-direct optimization of the device aiming to reduce the burden of late-onset RVF during the follow-up.

Original languageEnglish
Pages (from-to)2355-2364
Number of pages10
JournalJournal of Cardiac Surgery
Volume36
Issue number7
DOIs
StatePublished - Jul 2021
Externally publishedYes

Keywords

  • late right ventricular failure
  • left ventricle assist device
  • pump speed optimization
  • ramp test

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