A New Class of Photolabile Chelators for the Rapid Release of Divalent Cations: Generation of Caged Ca and Caged Mg

G. C.R. Ellis-Davies; J. H. Kaplan

doi:10.1021/jo00244a022

A New Class of Photolabile Chelators for the Rapid Release of Divalent Cations: Generation of Caged Ca and Caged Mg

G. C.R. Ellis-Davies, J. H. Kaplan

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85 Scopus citations

Abstract

The synthesis of 2-nitro-4,5-dimethoxyphenyl derivatives of EGTA and EDTA is reported. These tetracarboxylate chelators are designed for the rapid photochemically initiated release of divalent cations in intact physiological systems. The key step in the synthesis is the use of high-pressure synthetic technology for the construction of the tertiary amine moiety of both types of chelator.

Original language	English
Pages (from-to)	1966-1969
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	53
Issue number	9
DOIs	https://doi.org/10.1021/jo00244a022
State	Published - 1 Apr 1988
Externally published	Yes

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title = "A New Class of Photolabile Chelators for the Rapid Release of Divalent Cations: Generation of Caged Ca and Caged Mg",

abstract = "The synthesis of 2-nitro-4,5-dimethoxyphenyl derivatives of EGTA and EDTA is reported. These tetracarboxylate chelators are designed for the rapid photochemically initiated release of divalent cations in intact physiological systems. The key step in the synthesis is the use of high-pressure synthetic technology for the construction of the tertiary amine moiety of both types of chelator.",

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AB - The synthesis of 2-nitro-4,5-dimethoxyphenyl derivatives of EGTA and EDTA is reported. These tetracarboxylate chelators are designed for the rapid photochemically initiated release of divalent cations in intact physiological systems. The key step in the synthesis is the use of high-pressure synthetic technology for the construction of the tertiary amine moiety of both types of chelator.

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A New Class of Photolabile Chelators for the Rapid Release of Divalent Cations: Generation of Caged Ca and Caged Mg

Abstract

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