A new approach to gene mapping by in situ hybridization on isolated chromosomes

F. Wiener; J. Spira; M. Banerjee; G. Klein

doi:10.1007/BF01534843

A new approach to gene mapping by in situ hybridization on isolated chromosomes

F. Wiener, J. Spira, M. Banerjee, G. Klein

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6 Scopus citations

Abstract

A new technique was developed for in situ hybridization on isolated murine chromosomes. The safety and relative rapidity of the method is due to the ready availability of large numbers of isolated "target" chromosomes with well preserved morphology. Its applicability was demonstrated by mapping c-myc to band 15D of Robertsonian (6;15) fusion chromosomes. This localization coincides with the cytogenetic mapping of the translocation breakpoints in mouse plasmacytomas that carry the typical rcpt (12;15) translocation.

Original language	English
Pages (from-to)	493-498
Number of pages	6
Journal	Somatic Cell and Molecular Genetics
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/BF01534843
State	Published - Sep 1985
Externally published	Yes

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abstract = "A new technique was developed for in situ hybridization on isolated murine chromosomes. The safety and relative rapidity of the method is due to the ready availability of large numbers of isolated {"}target{"} chromosomes with well preserved morphology. Its applicability was demonstrated by mapping c-myc to band 15D of Robertsonian (6;15) fusion chromosomes. This localization coincides with the cytogenetic mapping of the translocation breakpoints in mouse plasmacytomas that carry the typical rcpt (12;15) translocation.",

author = "F. Wiener and J. Spira and M. Banerjee and G. Klein",

year = "1985",

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AU - Spira, J.

AU - Banerjee, M.

AU - Klein, G.

PY - 1985/9

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N2 - A new technique was developed for in situ hybridization on isolated murine chromosomes. The safety and relative rapidity of the method is due to the ready availability of large numbers of isolated "target" chromosomes with well preserved morphology. Its applicability was demonstrated by mapping c-myc to band 15D of Robertsonian (6;15) fusion chromosomes. This localization coincides with the cytogenetic mapping of the translocation breakpoints in mouse plasmacytomas that carry the typical rcpt (12;15) translocation.

AB - A new technique was developed for in situ hybridization on isolated murine chromosomes. The safety and relative rapidity of the method is due to the ready availability of large numbers of isolated "target" chromosomes with well preserved morphology. Its applicability was demonstrated by mapping c-myc to band 15D of Robertsonian (6;15) fusion chromosomes. This localization coincides with the cytogenetic mapping of the translocation breakpoints in mouse plasmacytomas that carry the typical rcpt (12;15) translocation.

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JO - Somatic Cell and Molecular Genetics

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A new approach to gene mapping by in situ hybridization on isolated chromosomes

Abstract

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