@inproceedings{6fdb3e148425493aa50eae787ebdd9be,
title = "A model for the role of integrins in flow induced mechanotransduction in osteyocytes",
abstract = "Recent studies demonstrate that osteocyte processes directly attach to the canalicular wall at discrete, infrequent collagen hillocks, most likely via integrins. In the current paper, we develop a model for these attachment complexes to determine whether they would induce focal strain amplification. Our model predicts that axial strains on the osteocyte process membrane in the vicinity of integrin-based attachments are approximately two orders of magnitude larger than whole bone tissue strains due to the sliding of actin filaments relative to integrin-based attachments. This large strain amplification can provide a mechanism for osteocyte excitation.",
author = "Y. Wang and McNamara, {L. M.} and Schaffler, {M. B.} and S. Weinbaum",
year = "2007",
doi = "10.1109/NEBC.2007.4413269",
language = "English",
isbn = "1424410339",
series = "Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "39--40",
booktitle = "33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC",
address = "United States",
note = "33rd Annual Northeast Bioengineering Conference, NEBC ; Conference date: 10-03-2007 Through 11-03-2007",
}