A mitosis-sensing caspase activation platform? New insights into the PIDDosome

Richa B. Shah, Ruth Thompson, Samuel Sidi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In contrast to the apoptosome and death-inducing signaling complex, the PIDDosome remains an orphan caspase activation platform unassigned to a specific apoptotic pathway. We found that DNA damage-induced PIDDosome formation is blocked by the mitotic checkpoint factor BUBR1 (budding uninhibited by benzimidazole-related 1), via a direct interaction that disrupts the PIDDosome core scaffold. This inhibition occurs at the kinetochore, thus physically connecting the mitotic and apoptotic machineries.

Original languageEnglish
Article numbere1059921
JournalMolecular and Cellular Oncology
Volume3
Issue number3
DOIs
StatePublished - 3 May 2016

Keywords

  • Apoptosis
  • BubR1
  • DNA damage
  • PIDD
  • PIDDosome
  • RAIDD
  • caspase-2
  • kinetochore
  • mitotic checkpoint

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