A mitochondrial expatriate: Nuclear pyruvate dehydrogenase

Vincent C.J. De Boer; Sander M. Houten

doi:10.1016/j.cell.2014.06.018

A mitochondrial expatriate: Nuclear pyruvate dehydrogenase

Vincent C.J. De Boer, Sander M. Houten

Research output: Contribution to journal › Short survey › peer-review

25 Scopus citations

Abstract

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.

Original language	English
Pages (from-to)	9-10
Number of pages	2
Journal	Cell
Volume	158
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2014.06.018
State	Published - 3 Jul 2014

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title = "A mitochondrial expatriate: Nuclear pyruvate dehydrogenase",

abstract = "The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.",

author = "{De Boer}, {Vincent C.J.} and Houten, {Sander M.}",

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T1 - A mitochondrial expatriate

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AU - Houten, Sander M.

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N2 - The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.

AB - The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.

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U2 - 10.1016/j.cell.2014.06.018

DO - 10.1016/j.cell.2014.06.018

M3 - Short survey

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SN - 0092-8674

VL - 158

SP - 9

EP - 10

JO - Cell

JF - Cell

IS - 1

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A mitochondrial expatriate: Nuclear pyruvate dehydrogenase

Abstract

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