A mitochondrial expatriate: Nuclear pyruvate dehydrogenase

Vincent C.J. De Boer, Sander M. Houten

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.

Original languageEnglish
Pages (from-to)9-10
Number of pages2
Issue number1
StatePublished - 3 Jul 2014


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