A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Anil Belur Nagaraj; Peronne Joseph; Erin Ponting; Yuriy Fedorov; Salendra Singh; Alex Cole; Woncheol Lee; Euisik Yoon; Alessia Baccarini; Peter Scacheri; Ronald Buckanovich; Drew J. Adams; Ronny Drapkin; Brian D. Brown; Analisa DiFeo

doi:10.1016/j.stemcr.2018.12.002

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Anil Belur Nagaraj
, Peronne Joseph
, Erin Ponting
, Yuriy Fedorov
, Salendra Singh
, Alex Cole
, Woncheol Lee
, Euisik Yoon
, Alessia Baccarini
, Peter Scacheri
, Ronald Buckanovich
, Drew J. Adams
, Ronny Drapkin
, Brian D. Brown
, Analisa DiFeo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.

Original language	English
Pages (from-to)	122-134
Number of pages	13
Journal	Stem Cell Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2018.12.002
State	Published - 8 Jan 2019

Keywords

BET inhibitors
miR-181a
miRNA sensor
ovarian cancer
tumor heterogeneity
tumor-initiating cells

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10.1016/j.stemcr.2018.12.002

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Belur Nagaraj, A., Joseph, P., Ponting, E., Fedorov, Y., Singh, S., Cole, A., Lee, W., Yoon, E., Baccarini, A., Scacheri, P., Buckanovich, R., Adams, D. J., Drapkin, R., Brown, B. D., & DiFeo, A. (2019). A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs. Stem Cell Reports, 12(1), 122-134. https://doi.org/10.1016/j.stemcr.2018.12.002

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title = "A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs",

abstract = "In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.",

keywords = "BET inhibitors, miR-181a, miRNA sensor, ovarian cancer, tumor heterogeneity, tumor-initiating cells",

author = "\{Belur Nagaraj\}, Anil and Peronne Joseph and Erin Ponting and Yuriy Fedorov and Salendra Singh and Alex Cole and Woncheol Lee and Euisik Yoon and Alessia Baccarini and Peter Scacheri and Ronald Buckanovich and Adams, \{Drew J.\} and Ronny Drapkin and Brown, \{Brian D.\} and Analisa DiFeo",

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year = "2019",

month = jan,

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doi = "10.1016/j.stemcr.2018.12.002",

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Belur Nagaraj, A, Joseph, P, Ponting, E, Fedorov, Y, Singh, S, Cole, A, Lee, W, Yoon, E, Baccarini, A, Scacheri, P, Buckanovich, R, Adams, DJ, Drapkin, R, Brown, BD & DiFeo, A 2019, 'A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs', Stem Cell Reports, vol. 12, no. 1, pp. 122-134. https://doi.org/10.1016/j.stemcr.2018.12.002

TY - JOUR

T1 - A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

AU - Belur Nagaraj, Anil

AU - Joseph, Peronne

AU - Ponting, Erin

AU - Fedorov, Yuriy

AU - Singh, Salendra

AU - Cole, Alex

AU - Lee, Woncheol

AU - Yoon, Euisik

AU - Baccarini, Alessia

AU - Scacheri, Peter

AU - Buckanovich, Ronald

AU - Adams, Drew J.

AU - Drapkin, Ronny

AU - Brown, Brian D.

AU - DiFeo, Analisa

PY - 2019/1/8

Y1 - 2019/1/8

N2 - In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.

AB - In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.

KW - BET inhibitors

KW - miR-181a

KW - miRNA sensor

KW - ovarian cancer

KW - tumor heterogeneity

KW - tumor-initiating cells

UR - https://www.scopus.com/pages/publications/85058776577

U2 - 10.1016/j.stemcr.2018.12.002

DO - 10.1016/j.stemcr.2018.12.002

M3 - Article

C2 - 30629937

AN - SCOPUS:85058776577

SN - 2213-6711

VL - 12

SP - 122

EP - 134

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 1

ER -

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Abstract

Keywords

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